N-Methyl-1H-Indole-5-EthaneSulphonamide Chemical Properties

Melting point:

124-125°C

Boiling point:

458.4±47.0 °C(Predicted)

Density 

1.316±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

11.52±0.40(Predicted)

color 

White to Off-White

N-Methyl-1H-Indole-5-EthaneSulphonamide Usage And Synthesis

Uses

N-Methyl-1H-indole-5-ethanesulfonamide is used as a reagent in the synthesis of Naratriptan Hydrochloride (N378730); a triptan drug used for the treatment of migraine headaches.

General Description

N-Methyl-1H-Indole-5-EthaneSulphonamide, also known as 2-(1H-Indol-5-yl)-N-methylethanesulfonamide, is a white solid.

Synthesis

At 40-45 ℃ (hydrogen pressure: 3-4 kg/cm2), 2-(3-Phenylsulf-anyl-1H-indol-5-yl)-ethanesulfonic acidmethylamide (14) (5 g, 0.014 mol) was hydrogenated in ethanol: water (7:3) (40 ml) in an autoclave for 10 h. After that, the reaction mass was cooled to room temperature, followed by removing the catalyst through filtering. The filtrate was distilled out to get N-Methyl-1H-Indole-5-EthaneSulphonamide. 

N-Methyl-1H-Indole-5-EthaneSulphonamide(98623-50-8)Related Product Information

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• Naratriptan Hydrochloride
• N-Methyl-1H-Indole-5-EthaneSulphonamide
• Naratriptan