N-METHYL-N-(4-NITROBENZYL)AMINE HYDROCHLORIDE Chemical Properties

Melting point:

218 °C

Boiling point:

277.2±15.0 °C(Predicted)

Density 

1.162±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

Solid

pka

8.86±0.10(Predicted)

Appearance

Brown to reddish brown Solid

CAS DataBase Reference

19499-60-6

Safety Information

Hazard Codes 

Xi

HS Code 

2921490090

N-METHYL-N-(4-NITROBENZYL)AMINE HYDROCHLORIDE Usage And Synthesis

Synthesis

GENERAL STEPS: To prepare N-methyl-4-nitrobenzylamine; 4-nitrobenzaldehyde (15.0 g, 99.3 mmol) and 40% aqueous methylamine (17 mL) in methanol (250 mL) were mixed for 15 min at 0 °C, followed by addition of sodium borohydride (3.77 g). The reaction mixture was stirred at room temperature for 2 hours and then concentrated. Water (50 mL) was added to the residue and extracted with dichloromethane (3 x 250 mL). The organic phases were combined, dried and concentrated to give the target product N-methyl-4-nitrobenzylamine. Yield 15.4 g, 94% yield.1H NMR (CDCl3) δ 8.10 (m, 2H), 7.43 (m, 2H), 3.79 (s, 2H), 2.39 (s, 3H).MS (AP+) m/e 167 (MH+).

References

[1] Patent: WO2008/4117, 2008, A1. Location in patent: Page/Page column 116
[2] Molecules, 2017, vol. 22, # 12,

N-METHYL-N-(4-NITROBENZYL)AMINE HYDROCHLORIDE(19499-60-6)Related Product Information

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