(S)-ALPHA-METHYL-4-NITROBENZYLAMINE HYDROCHLORIDE Chemical Properties

Melting point:

248-250 °C(lit.)

refractive index 

-7.2 ° (C=1, 0.05mol/L NaOH)

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

color 

White to Light yellow

optical activity

[α]25/D 6.5°, c = 1 in 0.05 M NaOH

Water Solubility 

faint turbidity

CAS DataBase Reference

132873-57-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

F 

3-10

HS Code 

29214990

MSDS

• Language:English Provider:SigmaAldrich

(S)-ALPHA-METHYL-4-NITROBENZYLAMINE HYDROCHLORIDE Usage And Synthesis

Uses

(S)-α-Methyl-4-nitrobenzylamine hydrochloride can be used as:

• A fluorescence-quenching guest in the determination of chiral recognition capabilities of binaphthocrown ether and polythiophene complex.
• A starting material in the synthesis of chiral cyclopalladated complexes with applications in the resolution of racemic compounds.

Purification Methods

To ensure dryness, the hydrochloride (ca 175 g) is extracted with EtOH (3x100mL) and evaporated to dryness (any residual H2O increases the solubility in EtOH and lowers the yield). The hydrochloride residue is triturated with absolute EtOH and dried in vacuo. The product is further purified by refluxing with absolute EtOH (200 mL for 83g) for 1hour, and cool to 10o to give 76.6g of hydrochloride m 243-245o(dec). The free base is prepared by dissolving in N NaOH, extracting with CH2Cl2 (3 x 500mL), drying (Na2CO3), filtering, evaporating and distilling it. It has m 27o, b 119-120o/0.5mm (105-107o/0.5mm, 157-159o/9mm, d 1.1764, n 1.5688, [] ±17.7o (neat) [Perry et al. Synthesis 492 1977,ORD: Nerdel & Liebig Justus Liebigs Ann Chem 621 142 1959]. [Beilstein 12 IV 2451.]

(S)-ALPHA-METHYL-4-NITROBENZYLAMINE HYDROCHLORIDE(132873-57-5)Related Product Information

• Ammonium sulfate
• Ethylamine hydrochloride
• (R)-ALPHA-METHYL-4-NITROBENZYLAMINE HYDROCHLORIDE
• S-(-)-a-Methyl-p-aminobenzylamine
• (S)-1-(4-NITROPHENYL)-ETHYLAMINE
• 4-Nitrobenzylamine hydrochloride
• ALFA-ALFA-DIMETHYL-P-NITRO-BENZYLAMINE HYDROCHLORIDE
• 4-(1-AMINO-ETHYL)-PHENYLAMINE
• (S)-ALPHA-METHYL-4-NITROBENZYLAMINE HYDROCHLORIDE
• (1R,2R)-(+)-1,2-Bis(4-nitrophenyl)ethylenediaminedihydrochloride,min.98%