(S)-1-(4-Nitrophenyl)ethylamine hydrochloride Chemical Properties

Melting point:

248-250 °C(lit.)

alpha 

-6.5 º (c=1, 0.05N NaOH)

storage temp. 

Inert atmosphere,Room Temperature

optical activity

[α]25/D +6.0°, c = 1 in 0.05 M NaOH

BRN 

3701567

CAS DataBase Reference

57233-86-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

F 

3-10

MSDS

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(S)-1-(4-Nitrophenyl)ethylamine hydrochloride Usage And Synthesis

Purification Methods

To ensure dryness, the hydrochloride (ca 175 g) is extracted with EtOH (3x100mL) and evaporated to dryness (any residual H2O increases the solubility in EtOH and lowers the yield). The hydrochloride residue is triturated with absolute EtOH and dried in vacuo. The product is further purified by refluxing with absolute EtOH (200 mL for 83g) for 1hour, and cool to 10o to give 76.6g of hydrochloride m 243-245o(dec). The free base is prepared by dissolving in N NaOH, extracting with CH2Cl2 (3 x 500mL), drying (Na2CO3), filtering, evaporating and distilling it. It has m 27o, b 119-120o/0.5mm (105-107o/0.5mm, 157-159o/9mm, d 1.1764, n 1.5688, [] ±17.7o (neat) [Perry et al. Synthesis 492 1977,ORD: Nerdel & Liebig Justus Liebigs Ann Chem 621 142 1959]. [Beilstein 12 IV 2451.]

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