N-Methyl-N-(4-methylbenzyl)amine Chemical Properties

Melting point:

70°C

Boiling point:

70 ºC (1 MMHG)

Density 

0.917±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

liquid

pka

9.98±0.10(Predicted)

color 

Colorless

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

22-34-36

Safety Statements 

36/37/39-26-23

HS Code 

2921490090

N-Methyl-N-(4-methylbenzyl)amine Usage And Synthesis

Synthesis

To a stirred solution of 4-methylbenzyl chloride (2.5 g, 17.85 mmol) in ethanol (15 ml) was slowly added 40% aqueous methylamine (5 ml) and stirred continuously for 4 h at room temperature. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove the solvent and subsequently quenched with deionized water (30 ml). The aqueous phase was extracted with dichloromethane (2 x 25 ml) and the organic phases were combined and dried with anhydrous sodium sulfate. The dried organic phase was concentrated under reduced pressure to afford N-methyl-N-(4-methylbenzyl)amine as a yellow oil (2.1 g, 87% yield).

References

[1] Patent: WO2009/109998, 2009, A1. Location in patent: Page/Page column 50
[2] Patent: WO2009/109999, 2009, A1. Location in patent: Page/Page column 70
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 20, p. 8073 - 8088
[4] Justus Liebigs Annalen der Chemie, 1931, vol. 490, p. 189,200
[5] Journal of Medicinal Chemistry, 1983, vol. 26, # 3, p. 309 - 312

N-Methyl-N-(4-methylbenzyl)amine(699-04-7)Related Product Information

• Methylparaben
• Benzyldimethylcarbinyl butyrate
• Benzyl chloromethyl ether
• Methanol
• N-Methyldiethanolamine
• Benzyltrimethylammonium hydroxide
• Dimethylbenzylcarbinyl acetate
• N,N,N',N'-Tetramethylethylenediamine
• METSULFURON METHYL
• Basic Violet 1
• Tribenuron methyl
• Kresoxim-methyl
• Methyl acrylate
• N,N-Dimethylbenzylamine
• Methyl salicylate
• N-Methyl-5-bromo-4,7-diazaindole
• Methyl
• Alizarin Complexone