N-Methyl-2-thiazolamine Chemical Properties

Boiling point:

174.5±23.0 °C(Predicted)

Density 

1.246±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

5.38±0.10(Predicted)

form 

liquid

color 

Brown

Safety Information

HS Code 

2934100090

N-Methyl-2-thiazolamine Usage And Synthesis

Synthesis

Synthesis of exemplary compound 14: N-methyl-N-(2-(methyl(thiazol-2-yl)amino)-2-oxoethyl)-3-phenylpropanamide; a) Synthesis of N-methylthiazol-2-amine; 900 μL (10 mmol) of 2-bromothiazole in 33% w/w ethanol methylamine solution (70 mL) was placed in an autoclave and heated to about 120 °C until system pressure The reaction mixture was stirred continuously for 2 h under these conditions. After completion of the reaction, the mixture was concentrated under reduced pressure and the residue was dissolved in a 3% w/v aqueous hydrochloric acid solution. The aqueous phase was subsequently washed with ether and the pH was adjusted to 12 with 20% w/v aqueous sodium hydroxide. the aqueous phase was saturated with sodium chloride and extracted with chloroform. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 761 mg (6.7 mmol, 67% yield) of N-methylthiazol-2-amine.

References

[1] Patent: US2009/176756, 2009, A1. Location in patent: Page/Page column 50

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