Naratriptan Hydrochloride

Product Name: Naratriptan Hydrochloride
CAS No.: 143388-64-1
Chemical Name: Naratriptan Hydrochloride
Synonyms: Naramig;Amerge.;GR-85548A;Nariptan Hydrochloride;GR-85548A hydrochloride;Naratriptan Nitrate USP;Naratriptan Hydrochloride;Naratryptan hydrochloride;Naratriptan monohydrochloride;Naratriptan HCl (GR-85548A HCl)
CBNumber: CB4500391
Molecular Formula: C17H25N3O2S.ClH
Formula Weight: 371.93
MOL File: 143388-64-1.mol

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Naratriptan Hydrochloride Property

Melting point:: 234-236°C
storage temp.: -20°C Freezer
solubility: H2O: ≥10mg/mL
form: powder
color: white to off-white
InChIKey: AWEZYKMQFAUBTD-UHFFFAOYSA-N

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
HS Code: 2935904000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N1415
Product name: Naratriptan hydrochloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $86
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1457469
Product name: Naratriptan hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 125mg
Price: $581
Updated: 2024/03/01

TCI Chemical

Product number: N1153
Product name: Naratriptan Hydrochloride
Packaging: 50MG
Price: $174
Updated: 2024/03/01

TCI Chemical

Product number: N1153
Product name: Naratriptan Hydrochloride
Packaging: 250MG
Price: $520
Updated: 2024/03/01

Cayman Chemical

Product number: 23754
Product name: Naratriptan (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $34
Updated: 2024/03/01

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Naratriptan Hydrochloride Chemical Properties,Usage,Production

Description

Naramig was launched in Germany, Sweden and the UK for use in migraine. It is chemically available via a number of related synthetic routes all having about three steps starting from 5-bromoindole. It is a new serotonin 5-HT_1B/1D receptor antagonist with modest affinity for 5-HT_1a, and very weak affinity for 5-HT₃ receptors. It has little or no affinity for a wide range of non-serotonin receptors including a- and padrenoceptors, dopamine, neurokinin NK₁, and opiate receptors. It mediates vasoconstriction in cerebral vasculature (extra cerebral intracranial vessels), reduces neurogenic inflammation, and inhibits responses mediated by the trigeminal nerves. It has a 6- and 3-fold greater affinity for 5-HT_1B, and 5-HT_1D, receptors, respectively, than sumatriptan which translates to a 2-3 fold increase in potency. The reoccurance of headache was less compared to sumatriptan, zolmitriptan and rizatriptan. Naramig had no clinical effects on blood pressure or heart rate, had a long duration of action with very good tolerability, and has high oral bioavailability.

Chemical Properties

Beige Solid

Originator

Glaxo Wellcome (UK)

Uses

Naratriptan Hydrochloride is a triptan drug that is used for the treatment of migraine headaches. It is a selective 5-hydroxytryptamine1 receptor subtype agonist

Uses

Naratriptan Hydrochloride is a triptan drug and is used for the treatment of migraine headaches

Uses

laxative

brand name

Amerge (GlaxoSmithKline).

Naratriptan Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Naratriptan Hydrochloride Suppliers

Americas 1 Canada 1 China 121 China Hong Kong 1 Europe 1 India 21 Japan 1 United Kingdom 1 United States 16 Global 164

shanghai Rainbow MediTech.Co.Ltd.

Tel: 21-021-64968085,64968086-5815,5812 13918693646
Fax: +86 21 64968087
Email: bd@rainbowpharma.cn
Country: China
ProdList: 946
Advantage: 65

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18217
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9984
Advantage: 60

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9823
Advantage: 79

Wuhan Arike Technology Co., Ltd.

Tel: 027- 51832457 94518350
Fax: E-Mail Inquiry
Country: China
ProdList: 746
Advantage: 62

Accendatech Co., LTD.

Tel: 13132578992
Fax: 022-83718543-802
Email: sales@accendatech.com
Country: China
ProdList: 332
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

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View Lastest Price from Naratriptan Hydrochloride manufacturers

Career Henan Chemical Co

Product: NARATRIPTAN HYDROCHLORIDE (125 MG)F0C3600.998MG/MG(AI) 143388-64-1
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

143388-64-1, Naratriptan HydrochlorideRelated Search:

Sumatriptan succinate Levetiracetam Sumatriptan CYCLAZOSIN HYDROCHLORIDE Varenicline tartrate Lenalidomide Lopinavir D-Glutamine 5,5-Diphenylhydantoin PLERIXAFOR Ethanesulfonamide Naratriptan Naratriptan Hydrochloride Naratriptan N-Methyl-1H-Indole-5-EthaneSulphonamide 5-METHYL-3-PIPERIDIN-4-YL-1H-INDOLE HCL

NARATRIPTAN HYDROCHLORIDE (125 MG)F0C3600.998MG/MG(AI)

Amerge.

Naramig

Naratriptan Hydrochloride

N-Methyl-2-[3-(1-methyl-4-piperidyl)-1H-indol-5-yl]-ethanesulfonamide Hydrochloride

GR-85548A hydrochloride

N-Methyl-3-(1-methylpiperidin-4-yl)-1H-indole-5-ethanesulfonamide hydrochloride

Naratriptan monohydrochloride

Naratriptan Hydrochloride (125 mg)

1H-Indole-5-ethanesulfonaMide,N-Methyl-3-(1-Methyl-4-piperidinyl

N-Methyl-2-(3-(1-Methylpiperidin-4-yl)-1H-indol-5-yl)ethanesulfonaMide hydrochloride

Nariptan Hydrochloride

Naratriptan Nitrate USP

1H-Indole-5-ethanesulfonaMide,N-Methyl-3-(1-Methyl-4-piperidinyl)-, hydrochloride (1:1)

GR-85548A

N-Methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide hydrochloride

1H-Indole-5-ethanesulfonamide,N-methyl-3-(1-methyl-4-piperidinyl)-,hydrochloride

NARATRIPTAN HYDROCHLORIDE (125 MG)F0C36099%8MG/MG(AI)

Naratriptan Hydrochloride USP/EP/BP

Naratryptan hydrochloride

Naratriptan HCl (GR-85548A HCl)

Naratriptan HydrochlorideQ: What is Naratriptan Hydrochloride Q: What is the CAS Number of Naratriptan Hydrochloride Q: What is the storage condition of Naratriptan Hydrochloride

Naratriptan Hydrochloride (1457469)

N-Methyl-2-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)ethane-1-sulfonamide hydrochloride

143388-64-1

C17H25N3O2SHCl

C17H25N3O2SClH

C17H26ClN3O2S

Amerge, Naramig

Pharmaceuticals

Inhibitors

APIs

Intermediates & Fine Chemicals