Varenicline tartrate
- Product Name
- Varenicline tartrate
- CAS No.
- 375815-87-5
- Chemical Name
- Varenicline tartrate
- Synonyms
- CS-291;Champix;Pidifix330;Pidifix-330;CP 526555-18;Unii-82269asb48;ChaMpix tartrate;Chantix tartrate;Varniclan tartrate;Varenicline tatrate
- CBNumber
- CB91011765
- Molecular Formula
- C17H19N3O6
- Formula Weight
- 361.35
- MOL File
- 375815-87-5.mol
Varenicline tartrate Property
- Melting point:
- 206-208°C
- storage temp.
- room temp
- solubility
- DMSO: >5mg/mL
- form
- powder
- color
- white to beige
- Stability:
- Hygroscopic
- InChI
- InChI=1/C13H13N3.C4H6O6/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1;5-1(3(7)8)2(6)4(9)10/h1-2,4-5,8-9,14H,3,6-7H2;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/s3
- InChIKey
- TWYFGYXQSYOKLK-UHFFFAOYSA-N
- SMILES
- [C@H](O)(C(=O)O)[C@@H](O)C(=O)O.C12=CC3=NC=CN=C3C=C1C1CNCC2C1 |&1:0,5,r|
Safety
- Hazard Codes
- Xn,N,T,F
- Risk Statements
- 22-50-39/23/24/25-23/24/25-11
- Safety Statements
- 22-57-45-36/37-16-7
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H400Very toxic to aquatic life
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PZ0004
- Product name
- Varenicline tartrate
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $149
- Updated
- 2024/03/01
- Product number
- PZ0004
- Product name
- Varenicline tartrate
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $591
- Updated
- 2024/03/01
- Product number
- 15030
- Product name
- Varenicline (tartrate)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 15030
- Product name
- Varenicline (tartrate)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $198
- Updated
- 2024/03/01
- Product number
- 15030
- Product name
- Varenicline (tartrate)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $467
- Updated
- 2024/03/01
Varenicline tartrate Chemical Properties,Usage,Production
Chemical Properties
Tan Solid
Uses
Nicotinic a4? acetylcholine receptor partial agonist. Aid in smoking cessation.
Uses
Varenicline tartrate is a prescription medication used to treat smoking addiction. Varenicline is a nicotinic receptor partial agonist. In this respect, it is similar to cytisine and different from the nicotinic antagonist, bupropion, and nicotine replacement ther
Uses
Nicotinic α4β2 acetylcholine receptor partial agonist. Aid in smoking cessation.
Definition
ChEBI: A tartrate salt obtained by reaction of varenicline with one equivalent of (R,R)-tartaric acid. A partial agonist for nicotinic cholinergic receptors, it is used as an aid to giving up smoking.
brand name
Chantix (Pfizer).
Biological Activity
Orally active, subtype-selective partial agonist at α 4 β 2 nicotinic receptors (K i values are 0.06, 240, 322 and 3540 nM for α 4 β 2, α 3 β 4, α 7, α 1 β γ δ receptors respectively). Reduces nicotine-evoked dopamine release in vitro and decreases nicotine self-administration in vivo .
Biochem/physiol Actions
Varenicline tartrate is a partial α4β2 nicotinic receptor agonist and α7 full agonist. Varenicline competitively binds to α4β2 receptors and partially stimulates without creating a full nicotine effect, while simultaneoudly blocking the ability of nicotine to bind to the receptors. Varenicline thus blocks the ability of nicotine to activate α4β2 receptors and stimulate the central nervous mesolimbic dopamine system, believed to be the neuronal mechanism underlying reinforcement and reward experienced upon smoking.
storage
Room temperature
Varenicline tartrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Varenicline tartrate manufacturers
- Product
- Varenicline tartrate 375815-87-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2019-12-27
- Product
- Varenicline tartrate 375815-87-5
- Price
- US $30.00-10.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-11-16
- Product
- Varenicline tartrate 375815-87-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 99.0%min
- Supply Ability
- 200kg
- Release date
- 2023-06-09