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Varenicline tartrate

Product Name
Varenicline tartrate
CAS No.
375815-87-5
Chemical Name
Varenicline tartrate
Synonyms
CS-291;Champix;Pidifix330;Pidifix-330;CP 526555-18;Unii-82269asb48;ChaMpix tartrate;Chantix tartrate;Varniclan tartrate;Varenicline tatrate
CBNumber
CB91011765
Molecular Formula
C17H19N3O6
Formula Weight
361.35
MOL File
375815-87-5.mol
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Varenicline tartrate Property

Melting point:
206-208°C
storage temp. 
room temp
solubility 
DMSO: >5mg/mL
form 
powder
color 
white to beige
Stability:
Hygroscopic
InChI
InChI=1/C13H13N3.C4H6O6/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1;5-1(3(7)8)2(6)4(9)10/h1-2,4-5,8-9,14H,3,6-7H2;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/s3
InChIKey
TWYFGYXQSYOKLK-UHFFFAOYSA-N
SMILES
[C@H](O)(C(=O)O)[C@@H](O)C(=O)O.C12=CC3=NC=CN=C3C=C1C1CNCC2C1 |&1:0,5,r|
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Safety

Hazard Codes 
Xn,N,T,F
Risk Statements 
22-50-39/23/24/25-23/24/25-11
Safety Statements 
22-57-45-36/37-16-7
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0004
Product name
Varenicline tartrate
Purity
≥98% (HPLC)
Packaging
5mg
Price
$149
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0004
Product name
Varenicline tartrate
Purity
≥98% (HPLC)
Packaging
25mg
Price
$591
Updated
2024/03/01
Cayman Chemical
Product number
15030
Product name
Varenicline (tartrate)
Purity
≥98%
Packaging
5mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
15030
Product name
Varenicline (tartrate)
Purity
≥98%
Packaging
10mg
Price
$198
Updated
2024/03/01
Cayman Chemical
Product number
15030
Product name
Varenicline (tartrate)
Purity
≥98%
Packaging
25mg
Price
$467
Updated
2024/03/01
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Varenicline tartrate Chemical Properties,Usage,Production

Chemical Properties

Tan Solid

Uses

Nicotinic a4? acetylcholine receptor partial agonist. Aid in smoking cessation.

Uses

Varenicline tartrate is a prescription medication used to treat smoking addiction. Varenicline is a nicotinic receptor partial agonist. In this respect, it is similar to cytisine and different from the nicotinic antagonist, bupropion, and nicotine replacement ther

Uses

Nicotinic α4β2 acetylcholine receptor partial agonist. Aid in smoking cessation.

Definition

ChEBI: A tartrate salt obtained by reaction of varenicline with one equivalent of (R,R)-tartaric acid. A partial agonist for nicotinic cholinergic receptors, it is used as an aid to giving up smoking.

brand name

Chantix (Pfizer).

Biological Activity

Orally active, subtype-selective partial agonist at α 4 β 2 nicotinic receptors (K i values are 0.06, 240, 322 and 3540 nM for α 4 β 2, α 3 β 4, α 7, α 1 β γ δ receptors respectively). Reduces nicotine-evoked dopamine release in vitro and decreases nicotine self-administration in vivo .

Biochem/physiol Actions

Varenicline tartrate is a partial α4β2 nicotinic receptor agonist and α7 full agonist. Varenicline competitively binds to α4β2 receptors and partially stimulates without creating a full nicotine effect, while simultaneoudly blocking the ability of nicotine to bind to the receptors. Varenicline thus blocks the ability of nicotine to activate α4β2 receptors and stimulate the central nervous mesolimbic dopamine system, believed to be the neuronal mechanism underlying reinforcement and reward experienced upon smoking.

storage

Room temperature

Varenicline tartrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Varenicline tartrate Suppliers

Canada 2 China 244 India 36 Japan 1 United Kingdom 4 United States 27 Global 314
Jiangxi ravel Biotechnology Co.,Ltd
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View Lastest Price from Varenicline tartrate manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Varenicline tartrate 375815-87-5
Price
US $0.00-0.00/KG
Min. Order
5mg
Purity
99%
Supply Ability
2000tons
Release date
2019-12-27
Hebei Yanxi Chemical Co., Ltd.
Product
Varenicline tartrate 375815-87-5
Price
US $30.00-10.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-16
Hangzhou ICH Biofarm Co., Ltd
Product
Varenicline tartrate 375815-87-5
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
99.0%min
Supply Ability
200kg
Release date
2023-06-09

375815-87-5, Varenicline tartrateRelated Search:

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  • VARENICLINE TARTRATE
  • Varenicline tartrate for research
  • 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine (2R,3R)-2,3- dihydroxybutanedioate
  • Champix
  • CP 526555-18
  • Varenicline Tartarate
  • CS-291
  • ,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro-
  • 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepinetartrate
  • 6,10-Methano-6H-pyrazino(2,3-H)(3)benzazepine, 7,8,9,10-tetrahydro-, (2R,3R)-2,3-dihydroxybutanedioate (1:1)
  • Unii-82269asb48
  • 7,8,9,10-Tetrahydro-
  • ChaMpix tartrate
  • Chantix tartrate
  • Varenicline tatrate
  • 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro-, (2R,3R)-2,3-dihydroxybutanedioate
  • Varenicline tartrate solution
  • 7,8,9,10-Tetrahydro-6H-6,10-methanoazepino-[4,5-g]quinoxaline (2R,3R)-2,3-dihydroxysuccinate
  • 7,8,9,10-Tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline (2R,3R)-2,3-Dihydroxysuccinic Acid
  • Varenicline tartrate USP/EP/BP
  • Varenicline Tartrate DISCONTINUED
  • Varenicline Tartrate (CP 526555-18)
  • Pidifix330
  • Pidifix-330
  • TLF3617 Pidifix 330
  • Varniclan tartrate
  • Vernicline Tartrate API
  • 375815-87-5
  • 75815-87-5
  • C13H13N3C4H6O6
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Heterocyclic Compounds
  • Inhibitors
  • Chantix, Champix
  • APIs
  • Pfizer compounds
  • Pharmaceuticals