ChemicalBook > CAS DataBase List > Naratriptan Hydrochloride

Naratriptan Hydrochloride

Product Name
Naratriptan Hydrochloride
CAS No.
143388-64-1
Chemical Name
Naratriptan Hydrochloride
Synonyms
Naramig;Amerge.;GR-85548A;Nariptan Hydrochloride;GR-85548A hydrochloride;Naratriptan Nitrate USP;Naratriptan Hydrochloride;Naratryptan hydrochloride;Naratriptan monohydrochloride;Naratriptan HCl (GR-85548A HCl)
CBNumber
CB4500391
Molecular Formula
C17H25N3O2S.ClH
Formula Weight
371.93
MOL File
143388-64-1.mol
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Naratriptan Hydrochloride Property

Melting point:
234-236°C
storage temp. 
-20°C Freezer
solubility 
H2O: ≥10mg/mL
form 
powder
color 
white to off-white
InChIKey
AWEZYKMQFAUBTD-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
HS Code 
2935904000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N1415
Product name
Naratriptan hydrochloride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$86
Updated
2024/03/01
Sigma-Aldrich
Product number
1457469
Product name
Naratriptan hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
125mg
Price
$581
Updated
2024/03/01
TCI Chemical
Product number
N1153
Product name
Naratriptan Hydrochloride
Packaging
50MG
Price
$174
Updated
2024/03/01
TCI Chemical
Product number
N1153
Product name
Naratriptan Hydrochloride
Packaging
250MG
Price
$520
Updated
2024/03/01
Cayman Chemical
Product number
23754
Product name
Naratriptan (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$34
Updated
2024/03/01
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Naratriptan Hydrochloride Chemical Properties,Usage,Production

Description

Naramig was launched in Germany, Sweden and the UK for use in migraine. It is chemically available via a number of related synthetic routes all having about three steps starting from 5-bromoindole. It is a new serotonin 5-HT1B/1D receptor antagonist with modest affinity for 5-HT1a, and very weak affinity for 5-HT3 receptors. It has little or no affinity for a wide range of non-serotonin receptors including a- and padrenoceptors, dopamine, neurokinin NK1, and opiate receptors. It mediates vasoconstriction in cerebral vasculature (extra cerebral intracranial vessels), reduces neurogenic inflammation, and inhibits responses mediated by the trigeminal nerves. It has a 6- and 3-fold greater affinity for 5-HT1B, and 5-HT1D, receptors, respectively, than sumatriptan which translates to a 2-3 fold increase in potency. The reoccurance of headache was less compared to sumatriptan, zolmitriptan and rizatriptan. Naramig had no clinical effects on blood pressure or heart rate, had a long duration of action with very good tolerability, and has high oral bioavailability.

Chemical Properties

Beige Solid

Originator

Glaxo Wellcome (UK)

Uses

Naratriptan Hydrochloride is a triptan drug that is used for the treatment of migraine headaches. It is a selective 5-hydroxytryptamine1 receptor subtype agonist

Uses

Naratriptan Hydrochloride is a triptan drug and is used for the treatment of migraine headaches

Uses

laxative

brand name

Amerge (GlaxoSmithKline).

Naratriptan Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Naratriptan Hydrochloride Suppliers

Americas 1 Canada 1 China 121 China Hong Kong 1 Europe 1 India 21 Japan 1 United Kingdom 1 United States 16 Global 164
shanghai Rainbow MediTech.Co.Ltd.
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View Lastest Price from Naratriptan Hydrochloride manufacturers

Career Henan Chemical Co
Product
NARATRIPTAN HYDROCHLORIDE (125 MG)F0C3600.998MG/MG(AI) 143388-64-1
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

143388-64-1, Naratriptan HydrochlorideRelated Search:

Sumatriptan succinate Levetiracetam Sumatriptan CYCLAZOSIN HYDROCHLORIDE Varenicline tartrate Lenalidomide Lopinavir D-Glutamine 5,5-Diphenylhydantoin PLERIXAFOR Ethanesulfonamide Naratriptan Naratriptan Hydrochloride Naratriptan N-Methyl-1H-Indole-5-EthaneSulphonamide 5-METHYL-3-PIPERIDIN-4-YL-1H-INDOLE HCL

  • NARATRIPTAN HYDROCHLORIDE (125 MG)F0C3600.998MG/MG(AI)
  • Amerge.
  • Naramig
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  • GR-85548A
  • N-Methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide hydrochloride
  • 1H-Indole-5-ethanesulfonamide,N-methyl-3-(1-methyl-4-piperidinyl)-,hydrochloride
  • NARATRIPTAN HYDROCHLORIDE (125 MG)F0C36099%8MG/MG(AI)
  • Naratriptan Hydrochloride USP/EP/BP
  • Naratryptan hydrochloride
  • Naratriptan HCl (GR-85548A HCl)
  • Naratriptan HydrochlorideQ: What is Naratriptan Hydrochloride Q: What is the CAS Number of Naratriptan Hydrochloride Q: What is the storage condition of Naratriptan Hydrochloride
  • Naratriptan Hydrochloride (1457469)
  • N-Methyl-2-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)ethane-1-sulfonamide hydrochloride
  • 143388-64-1
  • C17H25N3O2SHCl
  • C17H25N3O2SClH
  • C17H26ClN3O2S
  • Amerge, Naramig
  • Pharmaceuticals
  • Inhibitors
  • APIs
  • Intermediates & Fine Chemicals