- Product Name:
- Trospium chloride
- 2-hydroxy-2,2-diphenylacetic acid [(1S,5R)-3-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]yl] ester chloride
- (1a,3,5a)-3-[(2-Hydroxy-2,2-diphenylacetyl)oxy]-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-pyrrolidinium] Chloride
- Product Categories:
- Intermediates & Fine Chemicals
- Mol File:
Trospium chloride Chemical Properties
- Melting point:
- storage temp.
- Inert atmosphere,2-8°C
- Very soluble in water, freely soluble in methanol, practically insoluble in methylene chloride.
- Language:English Provider:Trospium chloride
Trospium chloride Usage And Synthesis
White to Off-White Crystalline Solid
Tropine derivative with anticholinergic activity, Trospium chloride can be used as Antispasmodic and used in treatment of urinary incontinence
An antimuscarinic compound that inhibits mAChR M
Labeled Trospium, intended for use as an internal standard for the quantification of Trospium by GC- or LC-mass spectrometry.
12.7 g of nortropine and 21.6 g 1,4-dibrombutane are heated, with stirring,for 14 hours at 38-40°C in 200 ml 70% ethanol in the presence of a strongly
basic ion exchanger. The reaction mixture is filtered, the filtrate brought to a
pH of 4-5 by addition of dilute hydrochloric acid, then evaporated to dryness
in a vacuum. The residue crystallized from ethanol-ether. Azoniaspiro-(3α-
hydroxy-nortropan-8,1'-pyrrolidine) chloride is obtained in a yield of about
51%; melting point 294-297°C.
2.17 g azoniaspiro-(3α-hydroxy-nortropan-8,1'-pyrrolidine) chloride and 4.24 g acetyl mandelic acid chloride are heated in a vacuum (12 mm Hg) for 6n hours at 100°C. After the addition of 40 ml water, the reaction mixture is repeatedly extracted, the aqueous phase adjusted to pH 6.7-6.8 and continuously extracted with chloroform for 24 hours. After the addition of 20 ml concentrated hydrochloric acid, the residue of the chloroform extract is left to stand for 15 hours at room temperature. The hydrochloric acid is then removed in a vacuum, the residue taken up in absolute ethanol, filtered through aluminum oxide. The filtrate evaporated to dryness and the residue crystallized from methanol-acetone. Azoniaspiro(3α-benziloyloxy-nortropan- 8,1'-pyrrolidine)-chloride is obtained in a yield of about 20%; melting point 197-198°C.
Trosoium chloride, 3α-benziloyloxynortropane-8-spiro-1' -pyrrolidinium chloride, (Sanctura)was available in Europe for almost 20 years before gainingapproval in the United States in May 2004. Much likeoxybutynin, it too is a competitive antagonist for muscarinicreceptors and is used to manage overactive bladder. Thequaternary amine reduces the likelihood that this agent willcross the blood-brain barrier. In addition, it has a limitedmetabolic profile, largely a result of its highly water-solublecharacteristics.
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- TROSPIUM IMPURITY B
- TROSPIUM IMPURITY A
- TROSPIUM IMPURITY C
- Mepiquat chloride
- Methyl benzilate
- Nortropine hydrochloride
- 4-PIPERIDINOL, PROPIONATE, HYDROCHLORIDE
- Trospium chloride
- Chloramine B
- Calcium chloride
- Choline chloride
- Methylene Chloride
- Ammonium chloride