Levosulpiride Chemical Properties

Melting point:

183-186 °C(lit.)

Density 

1.236±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMF (Slightly), DMSO (Slightly), Methanol (Slightly)

pka

9.98±0.60(Predicted)

form 

Solid

color 

White to Off-White

Merck 

14,8989

InChIKey

BGRJTUBHPOOWDU-NSHDSACASA-N

CAS DataBase Reference

23672-07-3(CAS DataBase Reference)

Safety Information

RIDADR 

3077

WGK Germany 

3

RTECS 

BZ3400100

HS Code 

29350090

Toxicity

LD50 oral in rabbit: > 1500mg/kg

MSDS

• Language:English Provider:SigmaAldrich

Levosulpiride Usage And Synthesis

Chemical Properties

White Solid

Uses

(S)-(?)-Sulpiride was used to study the effect of dopamine D₂ receptor function on activation of KCNQ potassium channels¹⁰ and on depression-like behavior in ovariectomized female rats.¹¹

Uses

dopamine receptor antagonists

Uses

Dopamine D2 and D3-receptor antagonist. Antipsychotic; antidepressant; antiemetic.

Definition

ChEBI: An optically active form of sulpiride having (S)-configuration. The active enantiomer of the racemic drug sulpiride. Selective D2-like dopamine antagonist (Ki values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 muM at D2, D3, D4, 1 and D5 receptors respectively).

General Description

(S)-(?)-Sulpiride is a levorotatory enantiomer of sulpiride, which shows greater central antidopaminergic activity, antiemetic and antidyspeptic effects. It is also used as a therapeutic drug for the treatment of depression and somatoform disorders.

Biological Activity

Active enantiomer. Selective D 2 -like dopamine antagonist (K i values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 μ M at D 2 , D 3 , D 4 , D 1 and D 5 receptors respectively).

Biochem/physiol Actions

(S)-(?)-Sulpiride or Levosulpiride blocks the inhibitory enteric D2 receptors (neuronal and muscular). It has prokinetic activity and is effective in the treatment of functional dyspepsia and gastroparesis in insulin-dependent diabetes mellitus patients.7,8 Since dopamine controls human sexual function, (S)-(?)-Sulpiride is reportedly effective in treatment of erectile dysfunctions.9

storage

Room temperature

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