2-(Aminomethyl)-1-ethylpyrrolidine Chemical Properties

Boiling point:

58-60 °C16 mm Hg(lit.)

Density 

0.884 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.4670(lit.)

Flash point:

135 °F

storage temp. 

2-8°C

solubility 

Chloroform (Sparingly), Methanol (Sparingly)

pka

10.04±0.40(Predicted)

form 

Liquid

color 

Clear yellow

InChI

InChI=1S/C7H16N2/c1-2-9-5-3-4-7(9)6-8/h7H,2-6,8H2,1H3

InChIKey

UNRBEYYLYRXYCG-UHFFFAOYSA-N

SMILES

N1(CC)CCCC1CN

LogP

0.433 (est)

CAS DataBase Reference

26116-12-1(CAS DataBase Reference)

NIST Chemistry Reference

2-Pyrrolidinemethanamine, 1-ethyl-(26116-12-1)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-36

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

HazardClass 

3.2

PackingGroup 

III

HS Code 

29339900

MSDS

• Language:English Provider:1-Ethylpyrrolidin-2-ylmethylamine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

2-(Aminomethyl)-1-ethylpyrrolidine Usage And Synthesis

Chemical Properties

clear yellow liquid

Uses

2-(Aminomethyl)-1-ethylpyrrolidine is used as a reagent in the synthesis of S-Desethyl S-Methyl Amisulpride (D289595)

Synthesis

General procedure for the synthesis of N-ethyl-2-aminomethylpyrrolidine from 1-ethyl-1H-pyrrole-2-carboxaldehyde: 60 g of 1-ethyl-1H-pyrrole-2-carboxaldehyde was added to an autoclave, and 5 g of palladium-carbon catalyst at a mass percent concentration of 5% and 15 g of liquid ammonia were added to carry out hydrogenation and reductive amination reactions. The reaction conditions were hydrogen pressure of 35 kg and temperature of 95°C. After completion of the reaction, the system was cooled, the gas was expelled, and filtration was carried out. The filter cake was washed with methanol, and the filtrate and washings were combined to recover methanol. Finally, the target product N-ethyl-2-aminomethylpyrrole was obtained by purification via decompression distillation in a yield of 53.7 g and 86%. The reaction equation was as follows:

References

[1] Patent: CN107973735, 2018, A. Location in patent: Paragraph 0017; 0027-0029

2-(Aminomethyl)-1-ethylpyrrolidine(26116-12-1)Related Product Information

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• 1-Methylpyrrolidine
• N-Methyl-2-pyrrolidone
• Ethyl formate
• Ethylbenzene
• Ethyl cellulose
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• METHYL-2-PYRROLIDONE
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