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(R)-Tomoxetine

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(R)-Tomoxetine Basic information

Product Name:
(R)-Tomoxetine
Synonyms:
  • n-methyl-3-(2-methylphenoxy)benzenepropanamine
  • (r)-tomoxetine
  • Tomoxetine
  • TomoxetineHcl
  • N-Methyl--(2-methylphenoxy)benzenepropanamine
  • N-Methyl-3-(2-methylphenoxy)-3-phenylpropylamine
  • (R)-N-Methyl-3-phenyl-3-(2-methylphenoxy)-1-propanamine
  • Methyl[(R)-3-phenyl-3-(2-methylphenoxy)propyl]amine
CAS:
83015-26-3
MF:
C17H21NO
MW:
255.36
EINECS:
617-427-9
Product Categories:
  • Inhibitors
  • Pharmacetes & Fine Chemicalsuticals
Mol File:
83015-26-3.mol
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(R)-Tomoxetine Chemical Properties

Boiling point:
389.0±37.0 °C(Predicted)
Density 
1.023±0.06 g/cm3(Predicted)
pka
10.15±0.10(Predicted)
CAS DataBase Reference
83015-26-3(CAS DataBase Reference)
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Safety Information

Safety Statements 
22-24/25
Hazardous Substances Data
83015-26-3(Hazardous Substances Data)
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(R)-Tomoxetine Usage And Synthesis

Uses

(R)-Tomoxetine is a compound active at novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases.

Definition

(R)-Tomoxetine is a secondary amino compound having methyl and 3-(2-methylphenoxy)-3-phenylpropan-1-yl substituents.

brand name

Strattera (Lilly).

in vivo

Atomoxetine (Tomoxetine) (0.3-3 mg/kg; i.p.; 0-4 hours; male Sprague-Dawley rats) increases extracellular norepinephrine and dopamine by 3-fold and increases Fos expression in the rat prefrontal cortex[1].
Atomoxetine (Tomoxetine) (0.1-5 mg/kg; i.p. and p.o; for 14 days; spontaneously hypertensive rat) can improve behaviors associated with ADHD in rats[3].

Animal Model:Male Sprague-Dawley rats[1]
Dosage:0.3, 1 and 3 mg/kg
Administration:Intraperitoneal injection; for 4 hours
Result:Increased the number of cells expressing Fos-like immunoreactivity in PFC 3.7-fold and increased extracellular norepinephrine and dopamine by 3-fold.
Animal Model:Spontaneously hypertensive rat (SHR)[3]
Dosage:0.1, 0.3, 1.25 and 5.0 mg/kg
Administration:Intraperitoneal injection and oral administration; for 14 days
Result:Had non-impact on the measurement of motor activity.

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