Terazosin hydrochloride dihydrate Chemical Properties

Melting point:

271-274°C

storage temp. 

Sealed in dry,Room Temperature

solubility 

Sparingly soluble in water, slightly soluble in methanol, very slightly soluble in ethanol (96 per cent), practically insoluble in acetone.

form 

Solid

color 

White

CAS DataBase Reference

70024-40-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

RTECS 

TK8046000

HS Code 

2934990002

Toxicity

LD50 in male, female rats (mg/kg): 277, 293 i.v. (Fort)

Terazosin hydrochloride dihydrate Usage And Synthesis

Chemical Properties

White or slightly yellow, crystalline powder.

Uses

analgesic, antiinflammatory

Uses

Terazosin Hydrochloride Dihydrate is an α-1-adrenergic blocker related to prazosin.

Manufacturing Process

To a solution of n-butanol (316 ml), water (24 ml) and N-(2- tetrahydrofuroyl)piperazine (20 g) were added, while stirring, 4-amino-2- chloro-6,7-dimethoxyquinazoline (22.2 g). The reaction mixture was heated to reflux and the reflux was maintained for about 9 h. Then the reaction mixture was cooled to room temperature and stirred at this temperature for about 10- 12 h. The crystals were collected by filtration, washed with n-BuOH and dried in vacuo at 40-50°C to yield 40.1 g (94%) of the 1-(4-amino-6,7-dimethoxy- 2-quinazolinyl)-4-(tetrahydrofuroyl)piperazine hydrochloride dihydrate

Therapeutic Function

Antihypertensive

Terazosin hydrochloride dihydrate (70024-40-7)Related Product Information

• Levodropropizine
• Terazosin hydrochloride
• Glycine
• Terazosin
• PYRAZOPHOS
• ALTRENOGEST
• N-Aminoethylpiperazine
• Piperacillin
• 2-Ethylhexyl ferulate
• [4-(4-AMino-7-hydroxy-6-Methoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)Methanone
• Tamsulosin
• Topotecan hydrochloride
• 2-Piperazine-4-amino-6,7-dimethoxyquinazoline
• Terazosin impurity
• (R)-Terazosin
• 2,2'-(1,4-Piperazinediyl)bis[6,7-diMethoxy-4-quinazolinaMine]
• 1-[4-(4-AMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl]-5-hydroxy-1-pentanone
• 6,7-DiMethoxy-2-(4-(tetrahydrofuran-2-carbonyl)piperazin-1-yl)quinazolin-4(1H)-one