Tropisetron hydrochloride Chemical Properties

Melting point:

283-285°C

RTECS 

NL6012520

storage temp. 

2-8°C

solubility 

H2O: >10mg/mL

form 

solid

color 

White to Light yellow

Water Solubility 

Soluble in water

Merck 

14,9783

InChI

InChI=1/C17H20N2O2.ClH/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16;/h2-5,10-13,15H,6-9H2,1H3;1H/t11-,12+,13?,15?;

InChIKey

ZAOQBEAHJFSJLY-NBVCILBMNA-N

SMILES

C12C=CC=CC=1N=CC2C(=O)OC1C[C@]2([H])N(C)[C@@]([H])(CC2)C1.Cl |&1:14,18,r|

CAS DataBase Reference

105826-92-4(CAS DataBase Reference)

Safety Information

RIDADR 

2811

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

III

HS Code 

29399990

Toxicity

mouse,LD50,intravenous,37900ug/kg (37.9mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 40, Pg. 2445, 1998.

Tropisetron hydrochloride Usage And Synthesis

Chemical Properties

White to Off-White Crystalline Solid

Uses

Specific serotonin (5-HT3) receptor antagonist. Antiemetic.

Uses

A selective 5-HT3 serotonin receptor antagonist

Definition

ChEBI: A hydrochloride obtained by combining equimolar amounts of tropisetron and hydrogen chloride.

Biological Activity

Potent, orally active 5-HT 3 receptor antagonist. Antiemetic.

Biochem/physiol Actions

Tropisetron a selective serotonin 5-HT3 receptor antagonist is used mainly as an antiemetic to treat nausea and vomiting following chemotherapy . In the treatment of fibromyalgia syndrome (FMS) tropisetron reduced not only pain perception but also had a favourable effect on cardiac dysfunction during treatment.

storage

Room temperature (desiccate)

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