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Tropisetron

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Tropisetron Basic information

Product Name:
Tropisetron
Synonyms:
  • TROPISETRON
  • 1H-Indole-3-carboxylic acid (1β,5β)-8-methyl-8-azabicyclo[3.2.1]octan-3α-yl ester
  • 1H-Indole-3-carboxylic acid, endo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
  • Tropisetron (ICS 205930)
  • 8-methyl-8-azabicyclo(3.2.1)oct-3-ylester,endo-1h-indole-3-carboxylicaci
  • icf205-930
  • 3-TROPANYL-INDOLE-3-CARBOXYLATE HYDROCHL ORIDE(ICS-205,930, NOVOBAN
  • 3-TROPANYL-INDOLE-3-CARBOXYLATE METHIODI DE ICS-205,930, METHIODI
CAS:
89565-68-4
MF:
C17H20N2O2
MW:
284.35
EINECS:
1806241-263-5
Mol File:
89565-68-4.mol
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Tropisetron Chemical Properties

Melting point:
201-202 °C
Boiling point:
448.5±35.0 °C(Predicted)
Density 
1.26
storage temp. 
Inert atmosphere,2-8°C
solubility 
H2O: soluble
form 
solid
pka
15.38±0.30(Predicted)
color 
white
CAS DataBase Reference
89565-68-4(CAS DataBase Reference)
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Safety Information

WGK Germany 
3
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Tropisetron Usage And Synthesis

Description

Tropisetron is the third selective 5HT3-antagonist, after ondansetron and granisetron, to be introduced for the management of nausea and vomiting induced by cancer chemotherapy. Similar to the other two 5HT3-antagonists, vopisetron is superior to metoclopramide. The compound has also been reported to have antiarrhythmic activity.

Originator

Sandoz (Switzerland)

Uses

A substance that is used to prevent nausea and vomiting caused by chemotherapy.

Definition

ChEBI: An indolyl carboxylate ester obtained by formal condensation of the carboxy group of indole-3-carboxylic acid with the hydroxy group of tropine.

brand name

Novaban

Hazard

Human systemic effects.

Tropisetron Preparation Products And Raw materials

Raw materials

Tropine

TropisetronSupplier

Shanghai Boyle Chemical Co., Ltd.
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sales@boylechem.com
Adamas Reagent, Ltd.
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400-6009262 16621234537
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chenyj@titansci.com
Wuhan Wei Shunda Technology Development Co., Ltd.
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86-027-88774375
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mwmwhot@163.com
LGM Pharma
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1-(800)-881-8210
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inquiries@lgmpharma.com
XiaoGan ShenYuan ChemPharm co,ltd
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15527768850
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1791901229@qq.com
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