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Digestive system drugs

Liver Disease drugs Antacid and Mucosal protective Drugs Cholagogue Drugs Other digestive system drugs Appetite suppressants and other diet pills Gastrointestinal motility drugs Gastrointestinal antispasmodic drugs Laxatives and Antidiarrheal Medicines Gastric Acid Inhibitors Emetics and antiemetics Digestant drugs
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There are various kinds of digestive diseases with the medication being highly complex and diverse. For the treatment of reflux esophagitis and esophageal diseases, we should apply antacids drugs, especially cimetidine (Tagamet) and so on. H2 receptor blockers have efficacy of neutralizing gastric acid for suppression of gastric acid secretion and reducing the stimulation effect. In recent years, the discovery of metoclopramide (domperidone)’s effect on enhancing the lower esophageal sphincter (LES) tension and its selection application has led to the improved prognosis.

Peptic ulcer and chronic gastritis are common digestive system diseases with high incidence rate and many treatment drugs. However, to date, we are still lack of specific treatment. Antacids drugs for neutralizing gastric acid are still widely used. Conventionally applied sodium bicarbonate, calcium and magnesium have been gradually eliminated. At present time, the commonly used drug is aluminum hydroxide. This drug should be taken in 1 ~ 2h after a meal and can neutralize the stomach acid for up to 3h. Its combination with anticholinergic drugs can alleviate spasm pain as well as inhibit the gastric acid secretion in the evening, doing good to eliminate the peptic ulcer.

At the 1950th to 1960th of the 20th century, commonly used anticholinergic drug is probanthine (propantheline bromide). After the 1970s when the H2 blockers have emerged, the efficacy of treating peptic ulcer has been significantly improved. With the progress of the study, ranitidine, famotidine and other new generations of H2 receptor blocker with stronger antacid effect and reduced side have been applied to clinical practice, leading to excellent results with rapid eliminated symptoms and increased ulcer healing rate.
It is noteworthy that, proton pump inhibitors – omeprazole (Losec) can not only strongly suppress the acid effect, but also increase gastric mucosal blood flow, strengthen the gastric mucosal barrier, playing a more active and effective role in the treatment of this disease.

Currently, the treatment of chronic gastritis, though, is not satisfactory, but for the treatment of bile reflux gastritis, application of aluminum hydroxide and sucralfate to adsorb bile salts and protect gastric mucosal barrier in combination with domperidone can yield good results. In recent years, it has been found that almost all kinds of duodenal ulcers can lead to antral gastritis with Helicobacter pylori (HP) lead to inflammatory lesions in more than 80% cases. Therefore, simultaneously application of some appropriate antibiotic treatment can play a good role in promoting ulcer healing, reducing the relapse, eliminating the inflammation and increasing the efficacy of treatment of peptic ulcer and chronic gastritis. Colloidal bismuth subcitrate can both stimulate mucus secretion, playing a protective role of protecting the gastric mucosal barrier and have certain effect on killing the HP. If being appropriately selected depending on the disease, the rational application of the drugs mentioned above can play a more effective role in improving the efficacy in treating peptic ulcer and chronic gastritis as well as improving the prognosis.

Pepsin and other digestive drugs are now known to have only limited efficacy. For the treatment of chronic pancreatitis caused protein, starch and fat indigestion, pancreatin (pancreatin tablets, multi-enzyme tablets) is still in use, but requiring larger doses to be effective.

There are not many domestic pharmaceutical formulations for treating constipation with commonly used laxatives including milk of Magnesia, phenolphthalein and liquid paraffin. There is very limited domestic application of antidiarrheal opiates agents. Commonly used include aluminum hydroxide gel and diphenoxylate. It is worth noting that the latter one has a similar effect as pethidine and is often prone to be addicted and thus being not appropriate for long-term use. Lactulose is a special indigestible type of disaccharide, being able to be decomposed into lactose and acetate in large intestine, playing the osmotic laxative effect. Acidified manure can inhibit the intestinal bacteria from producing ammonia, and enable ammonia to diffuse into the lumen of the colon. Therefore, it has effect of lowering blood ammonia, having certain therapeutic effect on the treatment of hepatic coma.

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Structure:
Chemical Name:
Alibendol
CAS:
26750-81-2
MF:
C13H17NO4
Structure:
Chemical Name:
Sofalcone
CAS:
64506-49-6
MF:
C27H30O6
Structure:
Chemical Name:
Alvimopan
CAS:
156053-89-3
MF:
C25H32N2O4
Structure:
Chemical Name:
REBAMIPIDE
CAS:
111911-87-6
MF:
C19H15ClN2O4
Structure:
Chemical Name:
Esomeprazole
CAS:
119141-88-7
MF:
C17H19N3O3S
Structure:
Chemical Name:
(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE
CAS:
846589-98-8
MF:
C11H15Cl2N
Structure:
Chemical Name:
Dolasetron mesylate
CAS:
115956-13-3
MF:
C20H26N2O7S
Structure:
Chemical Name:
Omeprazole
CAS:
73590-58-6
MF:
C17H19N3O3S
Structure:
Chemical Name:
Oleanic acid
CAS:
508-02-1
MF:
C30H48O3
Structure:
Chemical Name:
Esomeprazole sodium
CAS:
161796-78-7
MF:
C34H36MgN6O6S2
Structure:
Chemical Name:
Aprepitant
CAS:
170729-80-3
MF:
C23H21F7N4O3
Structure:
Chemical Name:
Dioctyl sulfosuccinate sodium salt
CAS:
577-11-7
MF:
C20H37O7S.Na
Structure:
Chemical Name:
3-Methoxy-1-propanol
CAS:
1589-49-7
MF:
C4H10O2
Structure:
Chemical Name:
Cholic acid
CAS:
81-25-4
MF:
C24H40O5
Structure:
Chemical Name:
Rebeprazole sodium
CAS:
117976-90-6
MF:
C18H20N3NaO3S
Structure:
Chemical Name:
Orlistat
CAS:
96829-58-2
MF:
C29H53NO5
Structure:
Chemical Name:
Rasagiline
CAS:
136236-51-6
MF:
C12H13N
Structure:
Chemical Name:
Glycyrrhizic acid ammonium salt
CAS:
53956-04-0
MF:
C42H65NO16
Structure:
Chemical Name:
GLYCOCHOLIC ACID SODIUM SALT
CAS:
863-57-0
MF:
C26H42NNaO6
Structure:
Chemical Name:
Glycyrrhizic acid
CAS:
1405-86-3
MF:
C42H62O16
Structure:
Chemical Name:
Dehydrocholic acid
CAS:
81-23-2
MF:
C24H34O5
Structure:
Chemical Name:
Ursodeoxycholic acid
CAS:
128-13-2
MF:
C24H40O4
Structure:
Chemical Name:
5-Aminosalicylic acid
CAS:
89-57-6
MF:
C7H7NO3
Structure:
Chemical Name:
Tiopronin
CAS:
1953-02-2
MF:
C5H9NO3S
Structure:
Chemical Name:
Calcium carbonate
CAS:
471-34-1
MF:
CCaO3
Structure:
Chemical Name:
LITHOCHOLIC ACID
CAS:
434-13-9
MF:
C24H40O3
Chemical Name:
K-CATALYST
CAS:
1318-93-0
MF:
Al2O9Si3
Structure:
Chemical Name:
Lipoic acid
CAS:
62-46-4
MF:
C8H14O2S2
Structure:
Chemical Name:
Citric acid monohydrate
CAS:
5949-29-1
MF:
C6H10O8
Structure:
Chemical Name:
Racecadotril
CAS:
81110-73-8
MF:
C21H23NO4S
Structure:
Chemical Name:
R-(-)-Apomorphine
CAS:
41372-20-7
MF:
C17H17NO2
Structure:
Chemical Name:
Rabeprazole
CAS:
117976-89-3
MF:
C18H21N3O3S
Structure:
Chemical Name:
Sodium sulfate
CAS:
7757-82-6
MF:
Na2SO4
Structure:
Chemical Name:
Phenolphthalein
CAS:
77-09-8
MF:
C20H14O4
Structure:
Chemical Name:
1,8-Dihydroxyanthraquinone
CAS:
117-10-2
MF:
C14H8O4
Structure:
Chemical Name:
Cimetidine
CAS:
51481-61-9
MF:
C10H16N6S
Structure:
Chemical Name:
Chenodeoxycholic acid
CAS:
474-25-9
MF:
C24H40O4
Structure:
Chemical Name:
L-carnitine
CAS:
541-15-1
MF:
C7H15NO3
Structure:
Chemical Name:
L-Carnitine-L-tartrate
CAS:
36687-82-8
MF:
C11H19NO8
Structure:
Chemical Name:
2-[(4-methoxy-3-methyl-pyridin-2-yl)methylsulfinyl]-5-pyrrol-1-yl-3H-benzoimidazole
CAS:
172152-36-2
MF:
C19H18N4O2S
Structure:
Chemical Name:
Castor oil
CAS:
8001-79-4
MF:
C57H104O9
Structure:
Chemical Name:
Aloin
CAS:
1415-73-2
MF:
C21H22O9
Structure:
Chemical Name:
Glycerol
CAS:
56-81-5
MF:
C3H8O3
Structure:
Chemical Name:
Famotidine
CAS:
76824-35-6
MF:
C8H15N7O2S3
Structure:
Chemical Name:
Bismuth trioxide
CAS:
1304-76-3
MF:
BiO3-
Structure:
Chemical Name:
4-Methylumbelliferone
CAS:
90-33-5
MF:
C10H8O3
Structure:
Chemical Name:
Diisopropylamine
CAS:
108-18-9
MF:
C6H15N
Structure:
Chemical Name:
Lansoprazole
CAS:
103577-45-3
MF:
C16H14F3N3O2S
Structure:
Chemical Name:
Sodium bicarbonate
CAS:
144-55-8
MF:
CHNaO3
Structure:
Chemical Name:
Esomeprazole magnesium
CAS:
161973-10-0
MF:
2(C17H18N3O3S)2.Mg
Structure:
Chemical Name:
Loperamide hydrochloride
CAS:
34552-83-5
MF:
C29H34Cl2N2O2
Structure:
Chemical Name:
Magnesium oxide
CAS:
1309-48-4
MF:
MgO
Structure:
Chemical Name:
3-Phenyl-1-propanol
CAS:
122-97-4
MF:
C9H12O
Structure:
Chemical Name:
1-Methylindazole-3-carboxylic acid
CAS:
107007-99-8
MF:
C18H25ClN4O
Chemical Name:
Bile salt ox
Structure:
Chemical Name:
Valethamate bromide
CAS:
90-22-2
MF:
C19H32BrNO2
Structure:
Chemical Name:
Bismuth subnitrate
CAS:
1304-85-4
MF:
Bi5H9N4O22
Structure:
Chemical Name:
Anethole trithione
CAS:
532-11-6
MF:
C10H8OS3
Structure:
Chemical Name:
Magnesium hydroxide
CAS:
1309-42-8
MF:
H2MgO2
Structure:
Chemical Name:
Disodium protoporphyrin IX
CAS:
50865-01-5
MF:
C34H32N4Na2O4
Structure:
Chemical Name:
Pantoprazole Sodium
CAS:
138786-67-1
MF:
C16H14F2N3NaO4S
Structure:
Chemical Name:
Protoporphyrin IX
CAS:
553-12-8
MF:
C34H34N4O4
Structure:
Chemical Name:
dolasetron
CAS:
115956-12-2
MF:
C19H20N2O3
Structure:
Chemical Name:
3-Pyridinecarboxylic acid N-hydroxymethylamide
CAS:
3569-99-1
MF:
C7H8N2O2
Structure:
Chemical Name:
Pirenzepine hydrochloride
CAS:
29868-97-1
MF:
C19H23Cl2N5O2
Chemical Name:
Ox Gallbladder powde
Structure:
Chemical Name:
BENACTYZINE HYDROCHLORIDE
CAS:
57-37-4
MF:
C20H26ClNO3
Structure:
Chemical Name:
3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID
CAS:
4651-67-6
MF:
C24H38O4
Structure:
Chemical Name:
Ranitidine Hydrochloride
CAS:
66357-59-3
MF:
C13H23ClN4O3S
Structure:
Chemical Name:
Poly(dimethylsiloxane)
CAS:
9016-00-6
MF:
C5H6Si
Structure:
Chemical Name:
Diammonium glycyrrhizinate
CAS:
79165-06-3
MF:
C42H62O16.2H3N
Structure:
Chemical Name:
Gabexate mesylate
CAS:
56974-61-9
MF:
C17H27N3O7S
Structure:
Chemical Name:
5-HYDROXY OMEPRAZOLE
CAS:
92340-57-3
MF:
C17H19N3O4S
Chemical Name:
BILE SALTS
MF:
C26H42NNaO6
Structure:
Chemical Name:
Ondansetron hydrochloride
CAS:
103639-04-9
MF:
C18H19N3O·HCl·2H2O
Structure:
Chemical Name:
Selegiline hydrochloride
CAS:
14611-52-0
MF:
C13H18ClN
Chemical Name:
Lactobacillin
Structure:
Chemical Name:
Rebamipide
CAS:
90098-04-7
MF:
C19H15ClN2O4
Structure:
Chemical Name:
L-Hyoscyamine
CAS:
101-31-5
MF:
C17 H23 N O3
Structure:
Chemical Name:
LORCASERIN
CAS:
616202-92-7
MF:
C11H14ClN
Structure:
Chemical Name:
MOSAPRIDE CITRATE DIHYDRATE
CAS:
636582-62-2
MF:
C27H33ClFN3O10
Structure:
Chemical Name:
Ondansetron
CAS:
99614-02-5
MF:
C18H19N3O
Structure:
Chemical Name:
Bismuth subcarbonate
CAS:
5892-10-4
MF:
CBi2O5
Structure:
Chemical Name:
Swertiamarine
CAS:
17388-39-5
MF:
C16H22O10
Structure:
Chemical Name:
Azasetron hydrochloride
CAS:
123040-69-7
MF:
C17H20ClN3O3
Structure:
Chemical Name:
Difenidol hydrochloride
CAS:
3254-89-5
MF:
C21H27NO
Structure:
Chemical Name:
R-(+)-Lansoprazole
CAS:
138530-94-6
MF:
C16H14F3N3O2S
Structure:
Chemical Name:
ALDIOXA
CAS:
5579-81-7
MF:
C4H7AlN4O5
Structure:
Chemical Name:
Irsogladine maleate
CAS:
84504-69-8
MF:
C13H11Cl2N5O4
Structure:
Chemical Name:
Pantoprazole
CAS:
102625-70-7
MF:
C16H15F2N3O4S
Structure:
Chemical Name:
ALOSETRON
CAS:
122852-42-0
MF:
C17H18N4O
Structure:
Chemical Name:
Magnesium trisilicate
CAS:
14987-04-3
MF:
Mg.O.Si
Structure:
Chemical Name:
Teprenone
CAS:
6809-52-5
MF:
C23H38O
Structure:
Chemical Name:
Tizanidine hydrochloride
CAS:
64461-82-1
MF:
C9H9Cl2N5S
Structure:
Chemical Name:
Domperidone
CAS:
57808-66-9
MF:
C22H24ClN5O2
Structure:
Chemical Name:
Cisapride
CAS:
81098-60-4
MF:
C23H29ClFN3O4
Structure:
Chemical Name:
Scopolamine butylbromide
CAS:
149-64-4
MF:
C21H30BrNO4
Structure:
Chemical Name:
Obeticholic Acid
CAS:
459789-99-2
MF:
C26H44O4
Structure:
Chemical Name:
Magnesium sulfate heptahydrate
CAS:
10034-99-8
MF:
Mg.O4S.7H2O
Structure:
Chemical Name:
Nizatidine
CAS:
76963-41-2
MF:
C12H21N5O2S2