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Gastrointestinal antispasmodic drugs

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Gastrointestinal antispasmodic drugs are mainly M receptor blockers, briefly referred to as anticholinergics, including belladonna alkaloids and their derivatives and artificial synthetic substitutes. For example: atropine, anisodamine, scopolamine, belladonna, trimebutine, and propanthine.

Mechanism These drugs function mainly through weakening the peristalsis function of the gastrointestinal tract, causing relaxation of the esophagus and gastrointestinal sphincter, thereby slowing down the stomach emptying and intestinal transport, weakening the gallbladder contraction and reducing the gallbladder pressure as well as weakening the colon peristalsis and slowing down the transport of colon contents.

Clinical anticholinergic drugs has atropine be the typical representative, mainly used for treating gastrointestinal dysfunction, relieving visceral colic, treating acute microcirculation and various kind of toxic shock and poisoning rescue and so on.

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Structure:
Chemical Name:
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MF:
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Chemical Name:
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149-64-4
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Chemical Name:
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985-12-6
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C24H32ClNO4
Structure:
Chemical Name:
Tizanidine
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51322-75-9
MF:
C9H8ClN5S
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Chemical Name:
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596-51-0
MF:
C19H28BrNO3-
Structure:
Chemical Name:
Drotaverin hydrochloride
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14009-24-6
MF:
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Structure:
Chemical Name:
Propantheline bromide
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50-34-0
MF:
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Structure:
Chemical Name:
Adiphenine hydrochloride
CAS:
50-42-0
MF:
C20H25NO2.ClH
Structure:
Chemical Name:
Methscopolamine bromide
CAS:
155-41-9
MF:
C18H24BrNO4
Structure:
Chemical Name:
Mebeverine hydrochloride
CAS:
2753-45-9
MF:
C25H35NO5.ClH
Structure:
Chemical Name:
Gefarnate
CAS:
51-77-4
MF:
C27H44O2
Structure:
Chemical Name:
ISOCORYDINE HYDROCHLORIDE
CAS:
13552-72-2
MF:
C20H24ClNO4
Structure:
Chemical Name:
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CAS:
50-10-2
MF:
C21H34BrNO3
Structure:
Chemical Name:
MEBEVERINE
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3625-06-7
MF:
C25H35NO5
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Structure:
Chemical Name:
octamylamine
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502-59-0
MF:
C40H88N
Structure:
Chemical Name:
MethylbenactyziumBromide
MF:
C21H28BrNO3
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CAS:
9010-34-8
Structure:
Chemical Name:
ATROPINE METHYL BROMIDE
CAS:
2870-71-5
MF:
C18H26BrNO3
Structure:
Chemical Name:
isometheptene
CAS:
503-01-5
MF:
C9H19N