Valethamate bromide Chemical Properties

Melting point:

120-127℃

RTECS 

BP7600000

storage temp. 

Inert atmosphere,Room Temperature

Water Solubility 

almost transparency in Water

solubility 

DMSO : 100 mg/mL (258.82 mM; Need ultrasonic)

form 

Powder

color 

White to Almost white

Merck 

14,9906

CAS DataBase Reference

90-22-2(CAS DataBase Reference)

Safety Information

HS Code 

2923.90.0100

MSDS

• Language:English Provider:Valethamate bromide

Valethamate bromide Usage And Synthesis

Originator

Murel,Ayerst,US

Definition

ChEBI: Valethamate bromide is an alkylbenzene.

Manufacturing Process

Benzyl cyanide is first reacted with 2-butylbromide in the presence of sodium amide to give 2-phenyl-3-methylvaleronitrile which is hydrolyzed by sulfuric acid to give 3-methyl-2-phenylpentanoic acid. 24 g of 2-phenyl-3- methylpentanoic acid are heated for one hour at 175° to 185°C with 30 g of 2-diethylaminoethanol and 0.5 g of sodium methylate. The excess diethylaminoethanol is removed in vacuo, the residue is dissolved in 300 cc of 2 N-acetic acid, the acid solution is shaken with ether and made alkaline with concentrated potassium carbonate solution and ice. The ether solution is washed with water, dried with sodium sulfate and evaporated. The residue is distilled under high vacuum, yielding 20 to 21 g of the basic ester (60% of the theoretical) is obtained, the ester boiling at 98° to 100°C at a pressure of 0.03 mm. The hydrochloride of the ester melts at 112°to 113°C and the methobromide at 100° to 101°C.

Therapeutic Function

Anticholinergic

Safety Profile

Poison by ingestion, subcutaneous, and intravenous routes. See also ESTERS and BROMIDES. When heated to decomposition it emits very toxic fumes of NOx, NH3, and Br-.

Valethamate bromide(90-22-2)Related Product Information

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