Drotaverin hydrochloride Chemical Properties

Boiling point:

520.94°C (rough estimate)

Density 

1.1507 (rough estimate)

refractive index 

1.6000 (estimate)

pka

6.17±0.20(Predicted)

Water Solubility 

13.75g/L(37 ºC)

InChI

InChI=1S/C24H31NO4/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20/h9-10,13-16,25H,5-8,11-12H2,1-4H3

InChIKey

OMFNSKIUKYOYRG-UHFFFAOYSA-N

SMILES

C1(=CC2=CC=C(OCC)C(OCC)=C2)C2=C(C=C(OCC)C(OCC)=C2)CCN1

CAS DataBase Reference

14009-24-6(CAS DataBase Reference)

Drotaverin hydrochloride Usage And Synthesis

Uses

Drotaverine is a selective phosphodiesterase 4 inhibitor with angina relief activity. Drotaverine is used to suppress angina, including pain in the gastrointestinal tract and biliary tract. Drotaverine may also cause compound-induced priapism, a side effect of sustained penile erection[1].

Definition

ChEBI: Drotaverine is a member of isoquinolines.

References

[1] Drotaverine-induced priapism DOI:10.4103/iju.IJU_240_20

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