- Product Name:
- DiisopropylaMine, >99.5%(GC)
- Product Categories:
- Heterocyclic Compounds
- Pharmaceutical Intermediates
- Mol File:
Diisopropylamine Chemical Properties
- Melting point:
- -61 °C (lit.)
- Boiling point:
- 84 °C (lit.)
- 0.722 g/mL at 25 °C (lit.)
- vapor density
- 3.5 (vs air)
- vapor pressure
- 50 mm Hg ( 20 °C)
- refractive index
- n20/D 1.392(lit.)
- Flash point:
- 1.4 °F
- storage temp.
- Store below +30°C.
- 100 g/L (20°C)
- 11.05(at 25℃)
- Clear colorless
- 11.8 (6g/l, H2O, 20℃)
- explosive limit
- Water Solubility
- 100 g/L (20 ºC)
- Exposure limits
- NIOSH REL: TWA 5 ppm (20 mg/m3), IDLH 200 ppm; OSHA PEL: TWA 5 ppm; ACGIH TLV: TWA 5 ppm (adopted).
- Stable. Flammable. Incompatible with strong oxidizing agents. May react violently with strong acids or oxidizers. Air sensitive.
- CAS DataBase Reference
- 108-18-9(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Propanamine, N-(1-methylethyl)-(108-18-9)
- EPA Substance Registry System
- Diisopropylamine (108-18-9)
- Hazard Codes
- Risk Statements
- Safety Statements
- UN 1158 3/PG 2
- WGK Germany
- Autoignition Temperature
- 599 °F
- Hazard Note
- Highly Flammable/Corrosive/Harmful
- HS Code
- 2921 19 99
- Hazardous Substances Data
- 108-18-9(Hazardous Substances Data)
- LD50 orally in rats: 0.77 g/kg (Smyth)
Diisopropylamine Usage And Synthesis
Diisopropylamine is a secondary amine and is a colorless liquid at room temperature with a fishy, ammonia-like odor. It is used as a chemical intermediate, and catalyst for the synthesis of pesticides and pharmaceuticals. Diisopropylamine is associated with tobacco either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. Synonyms for diisopropylamine include DIPA, and N-(1-methylethyl)-2- propanamine.
Diisopropylamine is a flammable, strongly alkaline Colorless liquid. Diisopropylamine is soluble in water and alcohol. The odor threshold ranges from 0.017 to 4.2 ppm; the fishlike odor becomes irritating at 100 mg/m3.
Colorless liquid with an ammonia-like odor. Experimentally determined detection and recognition odor threshold concentrations were 50 μg/m3 (130 ppbv) and 190 μg/m3 (380 ppbv), respectively (Hellman and Small, 1974).
Diisopropylamine is used as a solvent and in the chemical synthesis of dyes, pharmaceuticals, and other organic syntheses.
Diisopropylamine is used as a precursor to prepare lithium diisopropylamide and sulfenamides, which are used in rubber vulcanization. It is also involved in the synthesis of N,N-Diisopropylethylamine (Hünig's base) obtained by alkylation with diethyl sulfate. Diisopropylammonium bromide is a bromide salt of DIPA used as an inert alternative to barium titanate. It is widely used as solvent as well as an intermediate in the the synthesis of pharmaceuticals, dyes, mineral flotation agents and emulsifiers.
Diisopropylamine is produced by the reaction of diisopropyl alcohol with ammonia (HSDB 1989).
A clear colorless liquid with an ammonia-like odor. Flash point 30°F. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. Used to make other chemicals.
Air & Water Reactions
Highly flammable. Soluble in water. Sensitive to heat and air.
Diisopropylamine can react violently with oxidizing agents and strong acids. Readily eutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Permitted levels of diisopropylamine should not cause adverse health and welfare effects. Acute inhalation exposure to diisopropylamine can cause sore throat, cough, burning sensation and shortness of breath. Adverse effects occur mainly in the upper respiratory tract, although after chronic exposure. There is no definitive evidence that diisopropylamine causes cancer so a chronic cancer value was not developed. Diisopropylamine has not been classified as causing cancer by the International Agency for Research on Cancer, the United States Environmental Protection Agency, the American Conference of Industrial Hygienists, or the National Toxicology Program.
In humans, diisopropylamine is an eye irritant. When exposed to concentrations between 25 and 50 p.p.m., workers complained of disturbances of vision. There were also complaints of nausea and headache. Dermatitis would be expected from prolonged skin exposure (Beard and Noe, 1981).
Reactivity with Water No reaction; Reactivity with Common Materials: May attack some forms of plastics; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Diisopropylamine is used as a catalyst and as a stabilizer for mesityl oxide (HSDB 1989). It is also used as an intermediate in the synthesis of dyes, pharmaceuticals and pesticides (e.g. Diallate, Fenamiphos and Triallate).
Moderately toxic by ingestion and subcutaneous routes. Mildly toxic by inhalation. Mutation data reported. A skin and severe eye irritant. Inhalation of fumes can cause pulmonary edema. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. To fight fire, use alcohol foam,foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx See also AMINES.
Photolytic. Low et al. (1991) reported that the photooxidation of aqueous secondary amine
solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium
and nitrate ions.
Chemical/Physical. Reacts with acids forming water-soluble salts.
Little, if any investigation of the metabolism of short-chain aliphatic amines has been reported and the best that can be done is to suggest some possible metabolic routes. For example the flavin monooxygenase system could produce the hydroxylamine through N-hydroxylation catalyzed by the flavin monooxygenase system (Ziegler 1988). N-hydroxylation can also be induced with the cytochrome P-450 system as can N-dealkylation reactions (Lindeke and Cho 1982). More definitive analysis must await experimental studies.
Distil the amine from NaOH, or reflux it three minutes over Na wire or NaH, and distil it into a dry receiver under N2. [Beilstein 4 H 154, 4 I 369, 4 II 630, 4 III 274, 4 IV 510.]
Diisopropylamine Preparation Products And Raw materials
- 3-Carboxy-2,2,5,5-tetraMethylpyrrolidine 1-Oxyl Free Radical
- Diisopropylammonium dichloroacetate