- Product Name:
- iso-Propylamine gas
- Product Categories:
- HPLC and LCMS Mobile Phase Additive
- Mol File:
Isopropylamine Chemical Properties
- Melting point:
- -101 °C
- Boiling point:
- 33-34 °C(lit.)
- vapor density
- 2.04 (vs air)
- vapor pressure
- 9.2 psi ( 20 °C)
- refractive index
- n20/D 1.374(lit.)
- 4238 | ISOPROPYLAMINE
- Flash point:
- −26 °F
- storage temp.
- Crystalline Powder, Needles or Crystals
- 10.63(at 25℃)
- APHA: ≤50
- 13 (700g/l, H2O, 20℃)
- Strong ammoniacal; pungent, irritating, typical amine.
- explosive limit
- Water Solubility
- Air Sensitive
- JECFA Number
- Exposure limits
- TLV-TWA 5 ppm (～12 mg/m3) (ACGIH, MSHA, and OSHA); TLV-STEL 10 ppm(～24 mg/m3) (ACGIH); IDLH 4000 ppm (NIOSH).
- Stable. Extremely flammable - note low boiling point and low flash point. Readily forms explosive mixtures with air. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, perchloryl fluoride.
- CAS DataBase Reference
- 75-31-0(CAS DataBase Reference)
- NIST Chemistry Reference
- EPA Substance Registry System
- Hazard Codes
- Risk Statements
- Safety Statements
- UN 1221 3/PG 1
- WGK Germany
- Autoignition Temperature
- 755 °F
- HS Code
- 2921 19 99
- Hazardous Substances Data
- 75-31-0(Hazardous Substances Data)
- LD50 orally in rats: 820 mg/kg (Smyth)
Isopropylamine Usage And Synthesis
Colorless to yellow liquid; fishy ammonia aroma.
Colorless liquid with a penetrating, ammonia-like odor. Experimentally determined detection and recognition odor threshold concentrations were 500 μg/m3 (210 ppbv) and 1.7 mg/m3 (700 ppbv), respectively (Hellman and Small, 1974). An odor threshold concentration of 25 ppbv was reported by Nagata and Takeuchi (1990).
Not reported found in natu
Isopropylamine is used as a dehairing agentand as an intermediate in the preparation ofmany organics.
Solvent, intermediate in synthesis of rubber accelerators, pharmaceuticals, dyes, insecticides, bactericides, textile specialties, and surface-active agents, dehairing agent, solubilizer for 2,4-D acid.
Isopropylamine can be produced from the corresponding alcohol by reacting with ammonia in the presence of a dehydrating catalyst, or from the chloride by reacting with ammonia under pressure. It is also reported that this amine can be produced from acetone and ammonia or from the acetone oxime (HSDB 1989).
ChEBI: A member of the class of alkylamines that is propane carrying an amino group at position 2.
Aroma threshold values
High strength odor; fishy type; recommend smelling in a 0.10% solution or less.
A clear colorless liquid with an ammonia-like odor. Flash point -35°F. Boiling point 90°F. Less dense than water Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Used as a solvent and to make other chemicals.
Air & Water Reactions
Highly flammable. Water soluble.
Isopropylamine is a colorless, alkaline liquid, very volatile, moderately toxic, highly flammable. Dangerous fire hazard when exposed to heat, flame, sparks, or strong oxidizers. When heated to decomposition Isopropylamine emits toxic fumes of oxides of nitrogen [M. K.]. A mixture of Isopropylamine and perchloryl fluoride resulted in an uncontrolled oxidation and/or explosion, [J. Org. Chem., 1980, 45, 4036]. The reaction of 1-chloro-2,3-epoxypropane and the amine and most probably other nitrogen bases, yields a violent exotherm, [Chem. & Ind., 1971, 994].
Highly flammable, dangerous fire risk. Strong irritant to tissue.
Inhalation causes nose and throat irritation, severe coughing, and chest pain due to irritation of air passages; can cause lung edema and loss of consciousness. Ingestion causes nausea, salivation and severe irritation of mouth and stomach. Contact with eyes causes severe irritation and possible edema of the cornea. Contact with skin causes severe irritation.
Isopropylamine is a strong irritant to theeyes, skin, and respiratory system. A shortexposure to 10–20 ppm can cause irritationof the nose and throat in humans (Procturand Hughes 1978). Prolonged exposure tohigh concentrations may lead to pulmonaryedema. Skin contact can cause dermatitisand skin burns. Exposure to 8000 ppm for4 hours was lethal to rats.
LD50 value, oral (mice): 2200 mg/kg.
A brief exposure to 10-20 p.p.m. can result in irritation of the nose and throat. After exposure to the vapor for 8 h, workers have complained of visual disturbances. The liquid can produce severe eye burns and permanent visual impairment, and is irritating to the skin. Dermatitis can result from repeated exposure (Beard and Noe, 1981). A time-weighted average TLV of 5 p.p.m. has been established along with a STEL of 10 p.p.m. (ACGIH 1986).
Reactivity with Water No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Isopropylamine can be used as a dehairing agent and as a solvent. It also finds use as an intermediate in the production of insecticides, herbicides and bactericides and in the production of pharmaceuticals, dyes and rubber accelerators (HSDB 1989).
Photolytic. Low et al. (1991) reported that the photooxidation of aqueous primary amine
solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium
and nitrate ions.
Chemical/Physical. Releases toxic nitrogen oxides when heated to decomposition (Sax and Lewis, 1987). Forms water-soluble salts with acids.
One would expect isopropylamine to be readily absorbed from the gut and respiratory tract. Shorter chain aliphatic amines such as isopropylamine also are efficiently absorbed through the skin (Beard and Noe 1981). When administered intravenously, isopropylamine distributed rapidly into tissue compartments with tissue/plasma ratios ranging from 1.8 in the atrium to 16.7 in the renal medulla (Privitera et al 1982). During the elimination phase, a half-life of 146 min was observed in plasma. There do not appear to be any definitive metabolic studies with this compound, however through a comparison with other substrates, one might expect oxidation to acetone and ammonia through the action of monoamine oxidase (Tipton 1980).
Isopropylamine Preparation Products And Raw materials
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