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AMIPROFOS METHYL

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AMIPROFOS METHYL Basic information

Product Name:
AMIPROFOS METHYL
Synonyms:
  • amiprophosmethyl
  • bayntn6867
  • bayntn80
  • n-isopropyl-phosphoramidothioicacio-methylo-(2-nitro-p-tolyl)ester
  • ntn6867
  • O-METHYL O-(2-NITRO-P-TOLYL) N-ISOPROPYL-PHOSPHORAMIDOTHIONATE
  • AMIPROFOS METHYL
  • ntn80
CAS:
36001-88-4
MF:
C11H17N2O4PS
MW:
304.3
EINECS:
252-829-4
Mol File:
36001-88-4.mol
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AMIPROFOS METHYL Chemical Properties

Melting point:
~65 °C
Boiling point:
146.6°C
Density 
1.275±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
-0.73±0.70(Predicted)
form 
Solid
color 
White to Off-White
BRN 
2000833
EPA Substance Registry System
Amiprofos-methyl (36001-88-4)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
TB5100000
Toxicity
LD50 orl-rat: 309 mg/kg 85AREA 2,212,77

MSDS

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AMIPROFOS METHYL Usage And Synthesis

Description

Amiprofos-methyl (APM) is a phosphoric amide herbicide. It reversibly decreases H. vulgare root and shoot length and inhibits in vitro polymerization of Rosa tubulin induced by paclitaxel in a dose-dependent manner. APM completely inhibits tubulin polymerization in Hemanthus endosperm cells at a concentration of 0.1 μM. The antitubulin effects of APM are specific to plants as it has no effect on bovine brain tubulin polymerization at concentrations up to 100 μM. APM inhibits calcium accumulation in corn mitochondria (ID50 = 140 nM) and induces a 3-fold increase in the rate of calcium efflux from rat liver mitochondria at a concentration of 100 nM. APM inhibits the growth of P. falciparum (IC50 = 3.5 μM) and completely inhibits microtubule polymerization in P. falciparum trophozoites at a concentration of 20 μM.

Uses

Amiprofos-methyl is useful in herbicide compositions.

Biochem/physiol Actions

Herbicide that prevents microtubule polymerization in plant cells, but not animal cells. Crop plants resistant to amiprofos-methyl and several other herbicides have been developed by insertion of a xenobiotic-detoxifying human gene CYP2B6.

Safety Profile

A poison by ingestion. Lowtoxicity by skin contact. When heated to decomposition itemits toxic vapors of NOx, SOx, and POx.

AMIPROFOS METHYL Preparation Products And Raw materials

Raw materials

AMIPROFOS METHYLSupplier

Beijing VSciChem Technology Co., Ltd.
Tel
13811761079
Email
vscichem@163.com
Hangzhou J&H Chemical Co., Ltd.
Tel
+86-571-87396432 0571-87396433
Email
sales@jhechem.com
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Alta Scientific Co., Ltd.
Tel
022-6537-8550 15522853686
Email
sales@altasci.com.cn
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
18021002903
Email
3008007409@qq.com
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