AMIPROFOS METHYL
AMIPROFOS METHYL Basic information
- Product Name:
- AMIPROFOS METHYL
- Synonyms:
-
- amiprophosmethyl
- bayntn6867
- bayntn80
- n-isopropyl-phosphoramidothioicacio-methylo-(2-nitro-p-tolyl)ester
- ntn6867
- O-METHYL O-(2-NITRO-P-TOLYL) N-ISOPROPYL-PHOSPHORAMIDOTHIONATE
- AMIPROFOS METHYL
- ntn80
- CAS:
- 36001-88-4
- MF:
- C11H17N2O4PS
- MW:
- 304.3
- EINECS:
- 252-829-4
- Mol File:
- 36001-88-4.mol
AMIPROFOS METHYL Chemical Properties
- Melting point:
- ~65 °C
- Boiling point:
- 146.6°C
- Density
- 1.275±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- -0.73±0.70(Predicted)
- form
- Solid
- color
- White to Off-White
- BRN
- 2000833
- EPA Substance Registry System
- Amiprofos-methyl (36001-88-4)
MSDS
- Language:English Provider:SigmaAldrich
AMIPROFOS METHYL Usage And Synthesis
Description
Amiprofos-methyl (APM) is a phosphoric amide herbicide. It reversibly decreases H. vulgare root and shoot length and inhibits in vitro polymerization of Rosa tubulin induced by paclitaxel in a dose-dependent manner. APM completely inhibits tubulin polymerization in Hemanthus endosperm cells at a concentration of 0.1 μM. The antitubulin effects of APM are specific to plants as it has no effect on bovine brain tubulin polymerization at concentrations up to 100 μM. APM inhibits calcium accumulation in corn mitochondria (ID50 = 140 nM) and induces a 3-fold increase in the rate of calcium efflux from rat liver mitochondria at a concentration of 100 nM. APM inhibits the growth of P. falciparum (IC50 = 3.5 μM) and completely inhibits microtubule polymerization in P. falciparum trophozoites at a concentration of 20 μM.
Uses
Amiprofos-methyl is useful in herbicide compositions.
Biochem/physiol Actions
Herbicide that prevents microtubule polymerization in plant cells, but not animal cells. Crop plants resistant to amiprofos-methyl and several other herbicides have been developed by insertion of a xenobiotic-detoxifying human gene CYP2B6.
Safety Profile
A poison by ingestion. Lowtoxicity by skin contact. When heated to decomposition itemits toxic vapors of NOx, SOx, and POx.
AMIPROFOS METHYL Preparation Products And Raw materials
Raw materials
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