Amino-2-propanol Chemical Properties

Melting point:

-2 °C (lit.)

Boiling point:

160 °C (lit.)

Density 

0.973 g/mL at 25 °C (lit.)

vapor density 

2.6 (vs air)

vapor pressure 

<1 mm Hg ( 20 °C)

refractive index 

n20/D 1.4478(lit.)

FEMA 

3965 | 1-AMINO-2-PROPANOL

Flash point:

165 °F

storage temp. 

2-8°C

solubility 

DMSO : 250 mg/mL (3328.45 mM; Need ultrasonic)

pka

12.92±0.35(Predicted)

form 

Liquid

color 

Clear

PH

11.3 (10g/l, H2O, 20℃)

Odor

slt ammonia odor

Odor Type

fishy

explosive limit

1.9-10.4%(V)

Water Solubility 

freely soluble

FreezingPoint 

1.4℃

Sensitive 

Hygroscopic

JECFA Number

1591

BRN 

605275

Stability:

Stable. Substances to be avoided include strong oxidizing agents. Combustible. Hygroscopic.

InChIKey

HXKKHQJGJAFBHI-UHFFFAOYSA-N

LogP

-0.93 at 23℃

CAS DataBase Reference

78-96-6(CAS DataBase Reference)

NIST Chemistry Reference

2-Propanol, 1-amino-(78-96-6)

EPA Substance Registry System

Monoisopropanolamine (78-96-6)

Safety Information

Hazard Codes 

C,Xn

Risk Statements 

34-21/22

Safety Statements 

23-26-36-45-36/37

RIDADR 

UN 2735 8/PG 2

WGK Germany 

1

RTECS 

UA5775000

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29221980

Hazardous Substances Data

78-96-6(Hazardous Substances Data)

Toxicity

LD50 orl-rat: 1715 mg/kg GTPZAB 30(7),46,86

MSDS

• Language:English Provider:DL-Isopropanolamine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Amino-2-propanol Usage And Synthesis

Chemical Properties

colourless liquid

Chemical Properties

1-Amino-2-propanol has a fishy odor.

Occurrence

Reportedly present in sherry.

Uses

Synthetic and semisynthetic machine lubricating/cutting oil formulations have included isopropanolamine, diisopropanolamine, and triethanolamine, together with nitrites; consequently the EPA has promulgated standards regarding the composition of cutting fluids. No additional uses were found in the literature.

Uses

Amino-2-propanol is used to study the effect of temperature and water content on the molecular structure and hydrogen bonding of amino-2-propanol, which has been examined by Fourier transform near-infrared (FT-NIR) spectroscopy. Also used in used in the synthesis of protein kinase CK2 inhibitors used in the treatment of neoplasia and other infective diseases.

Uses

Amino-2-propanol can be used as a reactant to prepare:

• 5-methyl-2-oxazolidinone by oxidative carbonylation reaction using Pd(OAc)₂/I₂ catalyst.
• Bio-based polyurethanes by reacting with epoxidized soybean oil via ring-opening and amidation reaction.

It can also be used as a solvent as well as a template to synthesize layered aluminophosphate containing a racemic mixture of isopropanolamine.

Definition

ChEBI: Any amino alcohol that is propan-2-ol substituted by an amino group at position 1.

Preparation

By employing Salmonella, mutatant cobD, and aminopropanol

Aroma threshold values

Detection at 28 ppm in water

General Description

A colorless liquid with a slight ammonia-like odor. Less dense than water and soluble in water. Flash point 165°F. Corrosive to metals and tissue. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Used in plastics, paints, cutting oils, and specialized cleaning compounds.

Air & Water Reactions

Water soluble.

Reactivity Profile

Amino-2-propanol is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

Vapor irritates eyes and nose. Liquid causes local injury to mouth, throat, digestive tract, skin, and eyes.

Fire Hazard

Special Hazards of Combustion Products: Irritating vapors generated when heated.

Safety Profile

Poison by intraperitoneal route.Moderately toxic by ingestion and skin contact. A skin andsevere eye irritant. Moderately flammable in presence ofheat, flame, sparks, powerful oxidizers. Ignites on contactwith cellulose nitrate of high surface area. C

Amino-2-propanol(78-96-6)Related Product Information

• ALTRENOGEST
• Triisopropanolamine
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• EC 2.6.1.2
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• Isopropyl alcohol
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• (+)-DIOP
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• SAMARIUM(III) ISOPROPOXIDE
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