N-Isopropylacrylamide Chemical Properties

Melting point:

60-63 °C(lit.)

Boiling point:

89-92 °C2 mm Hg(lit.)

Density 

1.0223 (rough estimate)

refractive index 

1.4210 (estimate)

storage temp. 

2-8°C

form 

Crystalline Powder or Crystals

pka

14.83±0.46(Predicted)

color 

White to light yellow

PH

pH(50g/l, 25℃) : 7.8～10.0

Water Solubility 

Slightly soluble in water.

InChIKey

QNILTEGFHQSKFF-UHFFFAOYSA-N

LogP

0.278 (est)

CAS DataBase Reference

2210-25-5(CAS DataBase Reference)

NIST Chemistry Reference

Acrylamide, n-isopropyl-(2210-25-5)

EPA Substance Registry System

2-Propenamide, N-(1-methylethyl)- (2210-25-5)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36-36/37/38

Safety Statements 

26-36/37/39

WGK Germany 

3

RTECS 

AS3675000

TSCA 

Yes

HS Code 

29241990

Hazardous Substances Data

2210-25-5(Hazardous Substances Data)

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

N-Isopropylacrylamide Usage And Synthesis

Description

N-Isopropylacrylamide (NIPAM) is a biocompatible monomeric unit that can be used in the formation of stimuli responsive polymers due to its temperature sensitive properties, which include temperature-based volumetric and phase changes. These properties change when the temperature of the solution reaches a lower critical solution temperature (LCST).

Chemical Properties

white to light yellow crystalline powder or

Uses

NIPAM can be used to prepare poly(NIPAM) for a variety of applications such as tissue engineering, cell culture, biomedical coating, drug delivery, and muscle regeneration.

Uses

Binders in textiles, paper, adhesives, detergents, cosmetics.
N-Isopropylacrylamide is used to produce poly(N-isopropylacrylamide) (pNIPA, pNIPAAm, pNIPAA or pNIPAm) thermo sensitive polymer- or copolymer-based hydrogels. Polymers that contain NIPAM shrink dramatically above 33°C. Monomer used in the preparation of thermally sensitive, water-swellable hydrogels.

Application

N-Isopropylacrylamide (NIPAM) can be used to prepare poly(NIPAM) based thermosetting polymers, which can be used for a variety of applications such as tissue engineering, cell culture, biomedical coating, drug delivery, and muscle regeneration.
Monomer used in the preparation of thermally sensitive, water-swellable hydrogels.

General Description

N-Isopropylacrylamide (NIPAM) is a biocompatible monomeric unit that can be used in the formation of stimuli responsive polymers due to its temperature sensitive properties. These properties include temperature based volumetric and phase changes, which change when the temperature of the solution reaches a lower critical solution temperature (LCST).

Flammability and Explosibility

Not classified

Purification Methods

Fractionate the amide under reduced pressure, and recrystallise the solid distillate from hexane (m 59o), *C6H6 (m 62o) or *C6H6/hexane (m 62-63o). Store it with 0.05% of 4-tert-butylcatechol. It is used for making water soluble swellable hydrogels. [Beilstein 4 IV 517.]

N-Isopropylacrylamide(2210-25-5)Related Product Information

• N,N'-Methylenebisacrylamide
• Cocamidopropyl betaine
• Methacrylamide
• Acrylamide
• N-Hydroxyphthalimide
• CAPRYLOHYDROXAMIC ACID
• N-Cyclohexylmaleimide
• Bromacil
• N-TERT-BUTYLACRYLAMIDE
• N-TERT-OCTYLACRYLAMIDE
• Actinomycin D
• Terbacil
• N-[3-(2-Furyl)acryloyl]-L-phenylalanyl-glycyl-glycine
• Diacetone acrylamide
• Lenacil
• 2-Acrylamide-2-methylpropanesulfonic acid
• Poly[[N-isopropylacrylamide-co-[N-[3-(dodecyldimethylammonio)propyl]acrylamide]]phosphotungstate]
• POLY(N-ISOPROPYL ACRYLAMIDE)