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ChemicalBook >  Product Catalog >  Organic Chemistry >  Hydrocarbons and derivatives >  Acyclic hydrocarbons >  (1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane

(1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane

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(1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane Basic information

Product Name:
(1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane
Synonyms:
  • (3-Exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl] -8-Azabicyclo[3.2.1]octane
  • Des[1-(4,4-difluorocyclohexanecarboxamido)-1-phenylpropyl] Maraviroc
  • UK 408027
  • (1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane
  • 8-Azabicyclo[3,2,1]octane3-[3-methyl-5-(1-methlethyl)-4H-1,2,4-triazol-4-yl]-, (3-exo)-
  • Maraviroc Intermediate 2
  • Maraviroc interMediate(Tropinone)
  • (3-exo)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octane
CAS:
423165-07-5
MF:
C13H22N4
MW:
234.35
EINECS:
1533716-785-6
Product Categories:
  • Chiral Reagents
  • Metabolites & Impurities
Mol File:
423165-07-5.mol
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(1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane Chemical Properties

Melting point:
117 ºC
Boiling point:
402.4±55.0 °C(Predicted)
Density 
1.31
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Chloroform
form 
Solid
pka
10.71±0.40(Predicted)
color 
Off-White to Pale Yellow
InChI
InChI=1/C13H22N4/c1-8(2)13-16-15-9(3)17(13)12-6-10-4-5-11(7-12)14-10/h8,10-12,14H,4-7H2,1-3H3/t10-,11+,12-
InChIKey
CEIRCCADSFHOQD-ZSBIGDGJNA-N
SMILES
C(C1=NN=C(C)N1[C@@H]1C[C@H]2CC[C@H](N2)C1)(C)C |&1:7,9,12,r|
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Safety Information

HS Code 
2933592000
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(1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane Usage And Synthesis

Chemical Properties

Off-White to Pale Yellow Solid

Uses

A metabolite of Maraviroc.

Synthesis

 A solution of 8-benzyl-3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-aza-bicyclo[3.2.1]octane (2.0 g, 6.17 mmol) in methanol (30 mL) was treated with 10% palladium on carbon (0.25 g) under a hydrogen atmosphere (50 psi) at ambient temperature, overnight. The mixture was filtered through a pad of Celite and the filtrate was concentrated to give (1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane. Yield: 1.36 g (94%).

(1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octaneSupplier

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