ChemicalBook > Product Catalog > API > Digestive system drugs > Emetics and antiemetics > MOSAPRIDE CITRATE DIHYDRATE
MOSAPRIDE CITRATE DIHYDRATE
MOSAPRIDE CITRATE DIHYDRATE Basic information
- Product Name:
- MOSAPRIDE CITRATE DIHYDRATE
- Synonyms:
-
- 4-AMino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)Methyl]-2-Morpholinyl]Methyl]benzaMide 2-Hydroxy-1,2,3-propanetricarboxylate Hydrate
- Mosapride citrate salt dihydrate
- 4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl ]-2-morpholinyl]methyl]benzamide citrate dihydrate
- Mosapride dihydrate citrate
- MOSAPRIDE CITRATE DIHYDRATE USP/EP/BP
- 4-Amino-5-Chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide 2-hydroxypropane-1,2,3-tricarboxylate hydrate(1:1:2)
- GR 107719 B
- GR-107719-B
- CAS:
- 636582-62-2
- MF:
- C27H33ClFN3O10
- MW:
- 614.0164232
- Product Categories:
-
- Agonist
- Amines
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
- API
- Mol File:
- 636582-62-2.mol
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MOSAPRIDE CITRATE DIHYDRATE Chemical Properties
- Melting point:
- 112-114°C
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥5mg/mL
- form
- solid
- color
- White to off-white
- InChIKey
- HUZTYZBFZKRPFG-UHFFFAOYSA-N
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MOSAPRIDE CITRATE DIHYDRATE Usage And Synthesis
Chemical Properties
White Solid
Uses
A selective 5-HT4 receptor agonist. Gastroprokinetic.
Definition
ChEBI: Mosapride citrate dihydrate is a hydrate.
Biochem/physiol Actions
Mosapride is found effective against chronic gastritis, functional dyspepsia and gastro-oesophageal reflux disease. It is useful in treating many other symptoms associated with gastrointestinal disorders. Mosapride is known to improve digestive motility.
in vivo
Mosapride (Intravenous injection;0.3-3 mg/kg) dose-dependently increases the antral motor activity in conscious dogs which indicates that mosapride selectively stimulates upper gastrointestinal motility[2].
| Animal Model: | Beagle dogs[2] |
| Dosage: | 0.3-3 mg/kg |
| Administration: | Intravenous injection; 0.3-3 mg/kg |
| Result: | Increased the antral motor activity dose-dependently in conscious dogs. |
IC 50
5-HT4 Receptor; Kv4.3: 15.2 μM (IC50)
MOSAPRIDE CITRATE DIHYDRATESupplier
J & K SCIENTIFIC LTD.
- Tel
- 18210857532; 18210857532
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Chemsky（shanghai）International Co.,Ltd.
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- 021-50135380
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Nanjing Sunlida Biological Technology Co., Ltd.
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- 025-57798810
- sales@sunlidabio.com
TargetMol Chemicals Inc.
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- 021-021-33632979 15002134094
- marketing@targetmol.com
Sigma-Aldrich
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- 021-61415566 800-8193336
- orderCN@merckgroup.com