2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine Chemical Properties

Boiling point:

329.4±42.0 °C(Predicted)

Density 

1.613±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

-2.53±0.20(Predicted)

Appearance

Off-white to light yellow Solid

InChI

InChI=1S/C6H4Cl2N2S/c7-5-4-3(1-2-11-4)9-6(8)10-5/h1-2H2

InChIKey

CUVQFHMQHBMFCI-UHFFFAOYSA-N

SMILES

C1(Cl)=NC(Cl)=C2SCCC2=N1

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36

Safety Statements 

26

2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine Usage And Synthesis

Uses

2,4-Dichloro-6,7-dihydrothiophene[3,2-D]pyrimidine is a pyrimidine organic compound that can be used as a pharmaceutical intermediate.

Synthesis

General procedure for the synthesis of 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine (VII) from 6,7-dihydrothieno[3,2-d]pyrimidine-2,4-diol (VI): 2.4 g (14.1 mmol) of 6,7-dihydrothieno[3,2-d]pyrimidine-2,4-diol (VI) was suspended in 14 mL of phosphorus oxychloride and added with 4.5 mL (28.2 mmol) of diethylaniline and the mixture was stirred at 80 °C for 22 hours. Upon completion of the reaction, it was cooled to room temperature and the reaction mixture was slowly poured into ice water, the precipitate formed was collected by filtration and washed with cold water. The resulting precipitate was dissolved in dichloromethane and the water was removed by a phase separator. The organic phase was concentrated to dryness under reduced pressure to give 2.5 g of the target product VII in 85% yield.

References

[1] Organic Process Research and Development, 2016, vol. 20, # 5, p. 982 - 988
[2] Patent: WO2006/111549, 2006, A1. Location in patent: Page/Page column 61; 59; 65; 68; 69; 72; 74; 76; 84
[3] Patent: US2007/259846, 2007, A1. Location in patent: Page/Page column 30; 31
[4] Patent: WO2013/26797, 2013, A1. Location in patent: Page/Page column 24-25
[5] Patent: US2013/150341, 2013, A1. Location in patent: Paragraph 0364; 0365; 0366; 0367

2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine(74901-69-2)Related Product Information

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