PD 117519
PD 117519 Basic information
- Product Name:
- PD 117519
- Synonyms:
-
- (R)-N-(2,3-Dihydro-1H-indenyl)adenosine
- N-[(1R)-Indan-1-yl]adenosine
- N-[[(R)-2,3-Dihydro-1H-inden]-1α-yl]adenosine
- CI 947
- N-[(1R)-2,3-Dihydro-1H-inden-1-yl]adenosine
- PD 117519
- N-[(R)-Indan-1-yl]adenosine
- Adenosine, N-[(1R)-2,3-dihydro-1H-inden-1-yl]-
- CAS:
- 96392-15-3
- MF:
- C19H21N5O4
- MW:
- 383.4
- Product Categories:
-
- Bases & Related Reagents
- Carbohydrates & Derivatives
- Intermediates & Fine Chemicals
- Nucleotides
- Pharmaceuticals
- Mol File:
- 96392-15-3.mol
PD 117519 Chemical Properties
- storage temp.
- 2-8°C
- solubility
- DMF: 10mg/mL; DMF:PBS (pH 7.2) (1:4): 0.2mg/mL; DMSO: 5mg/mL; Ethanol: 0.1mg/mL
- form
- A solid
- color
- White to off-white
- InChIKey
- FSKMJUWPFLDDRS-BYMDKACISA-N
- SMILES
- OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N[C@H]3C4=C(C=CC=C4)CC3)N=C2)[C@H](O)[C@@H]1O
PD 117519 Usage And Synthesis
Uses
N6-Substituted adenosine receptor agonist; a potential antihypertensive agent.
in vitro
PD 117519 (2-10 mg/kg; oral administration; 16-24 hours; male beagle dogs) treatment produces significant hemodynamic changes at Tmax (4 hours) follows by acute coronary vascular injury that is evident at 16 hours postdosing.Treatment with 2 or 10 mg/kg of PD 117519 produces significant increases in mean heart rate and decreases in mean indirectsystolic blood pressure at time of highest drug exposure, 4 hours postdosing.
in vivo
PD 117519 (2-10 mg/kg; oral administration; 16-24 hours; male beagle dogs) treatment produces significant hemodynamic changes at Tmax (4 hours) follows by acute coronary vascular injury that is evident at 16 hours postdosing.Treatment with 2 or 10 mg/kg of PD 117519 produces significant increases in mean heart rate and decreases in mean indirectsystolic blood pressure at time of highest drug exposure, 4 hours postdosing[3].
| Animal Model: | 24 male beagle dogs (8-12 months old)[3] |
| Dosage: | 2 mg/kg or 10 mg/kg |
| Administration: | Oral administration; 16 hours and 24 hours |
| Result: | Increased in mean heart rate and decreased in mean indirectsystolic blood pressure at time of highest drug exposure. Induced acute coronary arteriopathy. The endothelium also appears injured. |
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