2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid
2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid Basic information
- Product Name:
- 2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid
- Synonyms:
-
- 2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid
- Gemcitabine Monophosphate
- 2',2'-Difluoro-2'-deoxycytidine 5'-phosphoric acid
- 2',2'-Difluoro-2'-deoxycytidine-5'-phosphoric acid
- Gemcitabine Monophosphate Formate Salt
- 2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid ForMate
- GeMcitabine Monophosphate disodiuM salt Monohydrate
- 2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate formate salt
- CAS:
- 116371-67-6
- MF:
- C9H12F2N3O7P
- MW:
- 343.18
- Product Categories:
-
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Phosphorylating and Phosphitylating Agents
- Bases & Related Reagents
- Nucleotides
- Mol File:
- 116371-67-6.mol
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2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid Chemical Properties
- Melting point:
- 151-153?C
- Boiling point:
- 618.3±65.0 °C(Predicted)
- Density
- 2.09
- storage temp.
- Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- solubility
- DMSO (Slightly), Water (Slightly)
- form
- Solid
- pka
- 1.86±0.10(Predicted)
- color
- White to Off-White
- Stability:
- Hygroscopic
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2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid Usage And Synthesis
Chemical Properties
White to Off-White Solid
Uses
Gemcitabine Monophosphate is a gemcitabine derivative. It is an antineoplastic agent.
Uses
Gemcitabine derivative. An antineoplastic agent
in vivo
Gemcitabine monophosphate (19.5 mg/kg, intravenous injection, every other day, four injections) combined with LCP loaded with VEGF siRNA and GMP shows anti-small cell lung cancer activity and induces apoptosis[1].
| Animal Model: | Subcutaneous and orthotopic xenograft mouse models of non-small cell lung cancer[1] |
| Dosage: | 19.5 mg/kg, every other day, four injections |
| Administration: | Intravenous injection (i.v.) |
| Result: | Induced tumor cell apoptosis to 30-40%, reduced tumor cell proliferation by 8 times, significantly reduced tumor microvessel density (MVD), and inhibited tumor mitosis. |
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