Basic information Safety Supplier Related

L-744,832

Basic information Safety Supplier Related

L-744,832 Basic information

Product Name:
L-744,832
Synonyms:
  • (2S)-[(2S)-[(2R)-AMINO-3-MERCAPTO]-PROPYLAMINO-(3S)-METHYL]PENTYLOXY-3-PHENYLPROPIONYL-METHIONINE SULFONE ISOPROPYL ESTER BIS HYDRCHLORIDE
  • L-744832
  • (2S)-[(2S)-[(2R)-Amino-3-mercapto]-propylamino-(3S)-methyl]pentyloxy-3-phenylpropionyl-methionine Sulfone Isopropyl Ester Bis Hydrchloride,
  • L-744,832 Dihydrochloride
  • L-744,832
  • L-744,832 - CAS 1177806-11-9 - Calbiochem
CAS:
1177806-11-9
MF:
C26H47Cl2N3O6S2
MW:
632.7
Product Categories:
  • Inhibitors
Mol File:
Mol File
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L-744,832 Chemical Properties

Melting point:
165-168°C
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
White solid
color 
White
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L-744,832 Usage And Synthesis

Chemical Properties

L-744,832 is White Cyrstalline Solid

Uses

L-744,832 is ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expressoin and arrests cells at G1. Causes enhanced mitotic

Uses

Ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expressoin and arrests cells at G1. Causes enhanced mitotic sensitivity to taxol.

General Description

A cell-permeable potent and selective thiol-containing peptidomimetic farnesyltransferase (FTase) inhibitor with anti-tumor properties. Rapidly blocks p70S6K activation and DNA synthesis and promotes apoptosis in transgenic mice. Induces p21 expression and cell cycle arrest in the G1 phase. Displays synergistic effect with paclitaxel and epothilones in inhibiting tumor growth. Also mimics many of the effects of Rapamycin (Cat. No. 553210) and may be effective against tumors that exhibit inappropriate activation of the mTOR/p70S6K pathway.

Biochem/physiol Actions

Cell permeable: yes

L-744,832Supplier

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
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