chaetomellic acid A Chemical Properties

form 

White to off-white solid.

chaetomellic acid A Usage And Synthesis

Uses

Chaetomellic acid A can be isolated from Chaetomella acutiseta. Chaetomellic acid A is a specific inhibitor of farnesyl-protein transferase. Chaetomellic acid A decreases oxidative stress-induced apoptosis in cells. Chaetomellic acid A reduces renal damage after unilateral ureteral obstruction (UUO) in mice[1][2].

References

[1] Nogueira A, et al. The Effects of Long-Term Chaetomellic Acid A Administration on Renal Function and Oxidative Stress in a Rat Model of Renal Mass Reduction. Biomed Res Int. 2017;2017:5125980. DOI:10.1155/2017/5125980
[2] Lingham RB, et al. Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protein transferase. Appl Microbiol Biotechnol. 1993 Nov;40(2-3):370-4. DOI:10.1007/BF00170395

chaetomellic acid A(148796-51-4)Related Product Information

• B581
• L-744,832
• ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID