plaunotol Chemical Properties

Boiling point:

440.4±45.0 °C(Predicted)

Density 

0.936±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

14.40±0.10(Predicted)

Safety Information

Toxicity

LD50 in male, female mice, rats (ml/kg): 8800, 8100, 10900, 11200 orally (Kobayashi)

plaunotol Usage And Synthesis

Description

Plaunotol is a diterpene alcohol extracted from the Thai plant, plau-noi. teprenone (2), it is reportedly useful as a cytoprotective anti-ulcer agent.

Chemical Properties

Pale yellow oily substance, with fragrance and bitter taste. Soluble in benzene, acetone, alcohol or ether, insoluble in water. Acute toxicity LD50 male and female mice, male and female rats (μl/kg, 1 μl-equivalent to 0.95mg of the product's refined oil): 8800, 8180, 10900, 11200 orally; 35500, 44000, 29500, 35000 subcutaneously.

Originator

Sankyo (Japan)

Uses

Plaunotol is a cytoprotective antiulcer agent that showed antibacterial activity against Helicobacter pylori and Staphylococcus aureus bacteria. It also enhanced the antibacterial activity of amoxycillin or clarithromycin antibiotics.

Definition

ChEBI: A diterpenoid that is geranylgeraniol carrying an additional hydroxy substituent at position 18.

brand name

Kelnac

plaunotol(64218-02-6)Related Product Information

• 2,6-OCTADIENE
• (E,E)-Farnesol
• plaunotol
• MANOALIDE