(E,E)-Farnesol Chemical Properties

Melting point:

61-63 °C

Boiling point:

149 °C4 mm Hg(lit.)

Density 

0.886 g/mL at 20 °C(lit.)

refractive index 

n20/D 1.490(lit.)

Flash point:

205 °F

storage temp. 

Sealed in dry,2-8°C

solubility 

Chloroform (Sparingly), DMSO (Slightly) Ethyl Acetate (Slightly)

pka

14.42±0.10(Predicted)

form 

Liquid

color 

Colourless

Odor

at 100.00 %. mild muguet floral sweet lily waxy

Odor Type

floral

Water Solubility 

Miscible with alcohol. Immiscible with water.

Sensitive 

Light Sensitive

BRN 

1723039

Stability:

Light Sensitive

InChIKey

CRDAMVZIKSXKFV-YFVJMOTDSA-N

LogP

5.31

CAS DataBase Reference

106-28-5(CAS DataBase Reference)

NIST Chemistry Reference

2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-, (E,E)-(106-28-5)

EPA Substance Registry System

(E,E)-Farnesol (106-28-5)

Safety Information

Hazard Codes 

Xi

Risk Statements 

43

Safety Statements 

24/25-36/37

WGK Germany 

3

RTECS 

JR4979000

F 

8

TSCA 

Yes

HS Code 

29052290

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

(E,E)-Farnesol Usage And Synthesis

Description

Farnesol is widely present in the flowers, leaves, stems and other parts of plants, especially in some Chinese herbal medicine plants and spice plants with a high content, such as Cinnamomum chinensis, Pinellia sinensis, loquat leaves, etc., which are well developed and utilized An important resource for prospects. Farnesol is one of the important active components of Chinese herbal medicine plants, and also one of the main fragrance components of some important essential oils of spice plants. Therefore, it has been widely used in medicine, pesticides, cosmetics and daily chemicals that require its biological activity.

Chemical Properties

Clear Colourless Oil

Uses

trans,trans-Farnesol is an intermediate used in the biological synthesis of cholesterol from mevalonic acid. It is used in the perfume industry. Further, it is used in the preparation of terpenes such as squalenes, cembranoids and forskolin. It is also used in the synthesis of Cecropia juvenile hormone.

Uses

Farnesol is a natural organic compound which is present in many essential oils.

Definition

ChEBI: Farnesol is a farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1. It has a role as a plant metabolite, a fungal metabolite and an antimicrobial agent. It is a farnesane sesquiterpenoid, a primary alcohol and a polyprenol.

Synthesis Reference(s)

Journal of the American Chemical Society, 102, p. 3298, 1980 DOI: 10.1021/ja00529a091
The Journal of Organic Chemistry, 40, p. 3617, 1975 DOI: 10.1021/jo00912a039

General Description

trans,trans-Farnesol is sesquiterpene alcohol, which is commonly found in many essential oils, citrus fruits, propolis, and plant-derived foods and beverages. It is an effective bioactive agent that can be used in pharmaceuticals and cosmetics.

Purification Methods

The main impurity is the cis-trans isomer. Purify it by gas chromatography using a 4ft x 0.125in 3%OV-1 column at 150o. [Corey et al. J Am Chem Soc 92 6637 1970, Popjak et al. J Biol Chem 237 56 1962.] It has also been fractionated through a 14-in Podbielniak column (p 11) at 11o/0.35mm. Alternatively it has been purified by gas chromatography using SF96 silicone on Fluoropak columns or Carbowax 20M on Fluoropak or base-washed 30:60 firebrick (to avoid decomposition, prepared by treating the firebrick with 5N NaOH in MeOH and washed with MeOH to pH 8) at 210o with Helium carrier gas at 60 mL/min flow rate. The diphenylcarbamoyl derivative has m 61-63o (from MeOH) and has an IR band at 3500 cm-1. [Bates et al. J Org Chem 28 1086 1963, Beilstein 1 IV 2335.]

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