GERANYLGERANIOL
GERANYLGERANIOL Basic information
- Product Name:
- GERANYLGERANIOL
- Synonyms:
-
- Geranylgeraniol (Natural)
- GERANYLGERANIOL
- Geranylgeraniol (mixture of isomers)
- 2,6,10,14-Hexadecatetraen-1-ol, 3,7,11,15-tetramethyl-, (2E,6E,10E)-
- (2E,6E,10E)-3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetren-1-ol
- (2E,6E,10E)-3,7,11,15-Tetramethylhexadecane-2,6,10,14-tetrene-1-ol
- all-E-Geranylgeraniol
- ALL TRANS-3,7,11,15-TETRAMETHYL-2,6,10,14-HEXADECATETRAEN-1-OL
- CAS:
- 24034-73-9
- MF:
- C20H34O
- MW:
- 290.48
- Product Categories:
-
- Miscellaneous Natural Products
- Mixed Fatty Acids
- Fatty Acid Derivatives & Lipids
- Glycerols
- Mol File:
- 24034-73-9.mol
GERANYLGERANIOL Chemical Properties
- Boiling point:
- 152-153 °C(Press: 0.07 Torr)
- Density
- 0.8930 g/cm3(Temp: 18 °C)
- storage temp.
- -20°C
- solubility
- Chloroform (Sparingly), Dichloromethane (Slightly), Ethyl Acetate (Slightly)
- form
- liquid
- pka
- 14.42±0.10(Predicted)
- color
- Colourless to Light Yellow
- BRN
- 1913779
- Stability:
- Light Sensistive, Temperature Sensitive
- InChI
- InChI=1S/C20H34O/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-21/h9,11,13,15,21H,6-8,10,12,14,16H2,1-5H3/b18-11+,19-13+,20-15+
- InChIKey
- OJISWRZIEWCUBN-QIRCYJPOSA-N
- SMILES
- C(O)/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(/C)\C
MSDS
- Language:English Provider:SigmaAldrich
GERANYLGERANIOL Usage And Synthesis
Chemical Properties
Light Yellow Oil
Uses
A intermediate in the lipidation of proteins, which plays a great importance for a variety of biological processes such as cell signalling
Uses
Geranylgeraniol, a precursor to Geranylgeranylpyrophosphate (G367600), is an intermediate in the mevalonate pathway. Geranylgeraniol has been shown to prevent bone re-adsorption, inhibition of osteoclast formation, and kinase activation in vitro.
Definition
ChEBI: Geranylgeraniol is a diterpenoid that is hexadeca-2,6,10,14-tetraene substituted by methyl groups at positions 3, 7, 11 and 15 and a hydroxy group at position 1. It has a role as a plant metabolite, a volatile oil component and an antileishmanial agent. It is a diterpenoid and a polyprenol.
Biochem/physiol Actions
As the pyrophosphate, the metabolic precursor of all diterpenes. Screening in vitro shows this to be a potent and selective agent against Mycobacterium tuberculosis.
in vivo
Geranylgeraniol (725 mg/kg/d; p.o.; 90 d) is not toxicologically significant with a dose below 725 mg/kg/d in rats[3].
Geranylgeraniol (483 mg/kg/d; p.o.; 10 d) suppresses lipopolysaccharide-induced inflammation via inhibition of nuclear factor-κB activation in rats[4].
| Animal Model: | Han Wistar rats (169-192 g for male; 116-152 g for female)[3] |
| Dosage: | 0, 725, 1450, and 2900 mg/kg |
| Administration: | Oral gavage; once daily; 90 days |
| Result: | Showed the lowest observed adverse effect level (LOAEL) for local effects and the no observed adverse effect level (NOAEL) for systemic effects as 725 mg/kg/d. Reduced body weights by 12.9 and 21.6% in the intermediate- and high-dose group males, respectively, compared to controls. |
| Animal Model: | Wistar rats (male, 8-week-old, 130-150 g)[4] |
| Dosage: | 0, 48.3, 483, 4830 mg/kg |
| Administration: | Oral gavage; once daily; 10 days; with or not LPS challenge (i.p.; 0.5 mg/kg) |
| Result: | Suppressed LPS-induced inflammatory cytokines and mRNA expression of LPS-induced inflammatory genes in liver with doses of 483 mg/kg and 4830 mg/kg. Suppressed protein levels of IRAK1, TRAF6, and TAK1, originating from transcriptional down-regulation with doses of 483 mg/kg and 4830 mg/kg. |
GERANYLGERANIOLSupplier
- Tel
- 18301977208
- 2126935757@qq.com
- Tel
- 0371-55289822 18737195735
- 483339295@qq.com
- Tel
- 0523-0523-86200346 15996028822
- 1583458435@qq.com
- Tel
- 15223382610
- danny@chemdad.com
- Tel
- 13564401937
- wangtao@jindipharma.com.cn