5'-CHLORO-2'-HYDROXY-4'-METHYLACETOPHENONE Chemical Properties

Melting point:

70-73 °C(lit.)

Boiling point:

137 °C / 15mmHg

Density 

1.250±0.06 g/cm3(Predicted)

form 

powder to crystal

pka

9.84±0.23(Predicted)

color 

White to Light yellow

CAS DataBase Reference

28480-70-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

2914.50.3000

MSDS

• Language:English Provider:SigmaAldrich

5'-CHLORO-2'-HYDROXY-4'-METHYLACETOPHENONE Usage And Synthesis

Uses

5′-Chloro-2′-hydroxy-4′-methylacetophenone (5-chloro-2-hydroxy-4-methylacetophenone) may be used in the preparation of the following:

• chalcones, required for the synthesis of novel pyrazoline derivatives
• 5′-chloro-2′-hydroxy-4′-methyl-3-(2′′-thienyl)acrylophenone
• 6-chloro-3-hydroxy-7-methyl-2-(2-thienyl)-4H-chromen-4-one, a complexing agent used for the spectrophotometric determination of vanadium(V)

Preparation

Preparation by reaction of acetic acid on 4-chloro-3- methylphenol with boron trifluoride at 70–100° (80–85%).

General Description

5′-chloro-2′-hydroxy-4′-methylacetophenone (5-Chloro-2-hydroxy-4-methylacetophenone) is a hydroxylated aromatic acetophenone. Its iodination by pyridinium iodochloride has been reported to afford 5-chloro-2-hydroxy-3-iodo-4-methylacetophenone.

5'-CHLORO-2'-HYDROXY-4'-METHYLACETOPHENONE(28480-70-8)Related Product Information

• 2'-Hydroxy-4'-methylacetophenone
• 5'-Chloro-2'-hydroxy-3'-nitroacetophenone
• 5-CHLORO-2-HYDROXY-4-METHYLBENZOPHENONE
• 5'-CHLORO-2'-HYDROXY-4'-METHYLACETOPHENONE
• 6-CHLORO-7-METHYLCHROMONE
• 6-CHLORO-3-CYANO-7-METHYLCHROMONE
• 6,4'-DICHLORO-7-METHYLFLAVONE
• 6-CHLORO-3-FORMYL-7-METHYLCHROMONE
• 5'-CHLORO-2'-HYDROXY-4'-METHYL-2-PHENYL ACETOPHENONE
• 5'-CHLORO-2'-HYDROXY-4'-METHYLPROPIOPHENONE
• 6-CHLORO-7-METHYL-4-OXO-4H-CHROMENE-2-CARBOXYLIC ACID
• 6-CHLORO-7-METHYLISOFLAVONE
• 3-BROMO-6-CHLORO-7-METHYLCHROMONE
• 1-(5-CHLORO-2-HYDROXY-4-METHYLPHENYL)-3-PHENYL-1,3-PROPANEDIONE
• 2',5-DICHLORO-2-HYDROXY-4-METHYLBENZOPHENONE
• 6-CHLORO-7-METHYLFLAVONE
• GEODIN
• 1-PHENYL-4(5-CHLORO-2-HYDROXY-4-METHYLBENZOYL)PYRAZOLE