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(R)-(+)-1-Phenylethyl isocyanate

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(R)-(+)-1-Phenylethyl isocyanate Basic information

Product Name:
(R)-(+)-1-Phenylethyl isocyanate
Synonyms:
  • ISOCYANIC ACID (R)-(+)-1-PHENYLETHYL ESTER
  • ISOCYANIC ACID (R)-(+)-ALPHA-METHYLBENZYL ESTER
  • (R)-(+)-1-PHENYLETHYL ISOCYANATE
  • (R)-1-PHENYLETHYLISOCYANATE
  • (R)-(+)-A-METHYLBENZYL ISOCYANATE
  • (R)-(+)-ALPHA-METHYLBENZYL ISOCYANATE
  • (R)(+)-ALPHA-PHENETHYL ISOCYANATE
  • (R) METHYL BENZYLISOCYANATE
CAS:
33375-06-3
MF:
C9H9NO
MW:
147.17
EINECS:
251-485-2
Product Categories:
  • chiral
  • Isocyanates (Chiral)
  • Analytical Chemistry
  • Chiral Building Blocks
  • e.e. / Absolute Configuration Determination (NMR)
  • e.e. Determination (HPLC Labeling Reagents)
  • Enantiomer Excess & Absolute Configuration Determination
  • for Resolution of Alcohols & Thiols
  • for Resolution of Bases
  • Optical Resolution
  • Synthetic Organic Chemistry
Mol File:
33375-06-3.mol
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(R)-(+)-1-Phenylethyl isocyanate Chemical Properties

Boiling point:
55-56 °C2.5 mm Hg(lit.)
alpha 
10 º (NEAT)
Density 
1.045 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.513(lit.)
Flash point:
150 °F
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Liquid
color 
Clear colorless to pale yellow
optical activity
[α]20/D +10°, neat
Water Solubility 
Decomposition
Sensitive 
Moisture Sensitive
BRN 
3196930
Stability:
Very Moisture sensitive
InChIKey
JJSCUXAFAJEQGB-UHFFFAOYSA-N
CAS DataBase Reference
33375-06-3(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn,T+,T
Risk Statements 
36/37/38-42-26-23/24/25-23
Safety Statements 
23-26-36-45-24/25-38-36/37/39-7/9
RIDADR 
UN 2206 6.1/PG 2
WGK Germany 
3
3-10-21
HazardClass 
6.1
PackingGroup 
III
HS Code 
29291090

MSDS

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(R)-(+)-1-Phenylethyl isocyanate Usage And Synthesis

Chemical Properties

Colorless to light yellow liqui

Uses

(R)-1-phenylethyl isocyanate is used in the derivatisation of alcohols, thiocarbamates and hydroxy fatty acids. (R)-1-phenylethyl isocyanate moderately inhibited both BP-DNA adducts.

General Description

(R)-(+)-a-Methylbenzyl isocyanate [(R)-(+)-MBIC] is a derivatizing agent.

Purification Methods

Purify the isocyanates by fractional distillation under a vacuum. With ammonia

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