METHYL 3,5-BIS(TRIFLUOROMETHYL)BENZOATE Chemical Properties

Boiling point:

85 °C

Density 

1.400±0.06 g/cm3 (20 ºC 760 Torr)

Flash point:

85-87°C/15mm

storage temp. 

Sealed in dry,Room Temperature

Appearance

Colorless to light yellow Liquid

CAS DataBase Reference

26107-80-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

Hazard Note 

Irritant

HS Code 

2916310090

MSDS

• Language:English Provider:ALFA

METHYL 3,5-BIS(TRIFLUOROMETHYL)BENZOATE Usage And Synthesis

Synthesis

To the reaction system was added 25.9 g (0.8 mol) of methanol, and after chlorine-fluorine exchange using HF according to the method of Example 2, 13.8 g (0.053 mol) of 3,5-bis(trifluoromethyl)benzoyl fluoride fraction was obtained, which was added slowly and dropwise to the reaction system over 60 minutes. Subsequently, the reaction mixture was stirred at 40°C for 4 hours. The generation of 14.2 g (0.052 mol) of methyl 3,5-bis(trifluoromethyl)benzoate was confirmed by gas chromatographic analysis (yield: 98%, selectivity: 100%). By vacuum distillation, 13.9 g (0.05 mol) of methyl 3,5-bis(trifluoromethyl)benzoate was isolated (yield: 96%). Examples 17-31 Various (fluoroalkyl)benzene derivatives were prepared with reference to the methods of Examples 2-16. To improve the purity of the product, Example 17 was purified by crystallization twice, and the final distillation step was repeated in the remaining Examples. The purity, residual halogen content and residual metal content of all (fluoroalkyl)benzene derivatives are summarized in Table 2.

References

[1] Patent: EP1500641, 2005, A1. Location in patent: Page 10; 15

METHYL 3,5-BIS(TRIFLUOROMETHYL)BENZOATE(26107-80-2)Related Product Information

• 3,5-Bis(trifluoromethyl)benzoic acid
• METHYL 3,5-BIS(TRIFLUOROMETHYL)BENZOATE
• (1-METHYL-3-PHENYL-5-([3-(TRIFLUOROMETHYL)PHENYL]SULFONYL)-1H-PYRAZOL-4-YL)METHYL 3,5-BIS(TRIFLUOROMETHYL)BENZENECARBOXYLATE
• RARECHEM AL FE 0083
• ETHYL 3,5-BIS(TRIFLUOROMETHYL)BENZOATE
• (1-METHYL-3-PHENYL-5-[3-(TRIFLUOROMETHYL)PHENOXY]-1H-PYRAZOL-4-YL)METHYL 3,5-BIS(TRIFLUOROMETHYL)BENZENECARBOXYLATE
• (5-[(2-CHLOROPHENYL)SULFANYL]-1-METHYL-3-PHENYL-1H-PYRAZOL-4-YL)METHYL 3,5-BIS(TRIFLUOROMETHYL)BENZENECARBOXYLATE
• (1-METHYL-3-PHENYL-5-([3-(TRIFLUOROMETHYL)PHENYL]SULFANYL)-1H-PYRAZOL-4-YL)METHYL 3,5-BIS(TRIFLUOROMETHYL)BENZENECARBOXYLATE
• (5-[(4-CHLOROPHENYL)SULFANYL]-1-METHYL-3-PHENYL-1H-PYRAZOL-4-YL)METHYL 3,5-BIS(TRIFLUOROMETHYL)BENZENECARBOXYLATE
• (5-[(4-CHLOROPHENYL)SULFONYL]-1-METHYL-3-PHENYL-1H-PYRAZOL-4-YL)METHYL 3,5-BIS(TRIFLUOROMETHYL)BENZENECARBOXYLATE