4-METHOXY-3-NITRO-BENZENEACETIC ACID METHYL ESTER Chemical Properties

Melting point:

100-102°

Boiling point:

356.8±27.0 °C(Predicted)

Density 

1.264±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

Appearance

White to off-white Solid

Safety Information

HazardClass 

IRRITANT

4-METHOXY-3-NITRO-BENZENEACETIC ACID METHYL ESTER Usage And Synthesis

Synthesis

General procedure for the synthesis of methyl 2-(4-methoxy-3-nitrophenyl)acetate from methyl 2-(4-hydroxy-3-nitrophenyl)acetate and iodomethane: To a solution of methyl 2-(4-hydroxy-3-nitrophenyl)acetate (4.87 g, 23.1 mmol) was added K2CO3 (8 g, 58 mmol) at room temperature, followed by slow addition of CH3I ( 6.6 g, 46.5 mmol). The reaction mixture was stirred at room temperature overnight. After the reaction was completed, the mixture was poured into ice water (100 mL) and extracted with CH2Cl2 (3 x 300 mL). The organic layers were combined, washed with brine, dried over Na2SO4, filtered and concentrated to give methyl 2-(4-methoxy-3-nitrophenyl)acetate (5 g, 96% yield) as a yellow solid.LCMS analysis showed an [M + H]+ of 226.0; retention time (Rt) of 1.438 min.

References

[1] Patent: WO2013/19682, 2013, A1. Location in patent: Page/Page column 106; 107

4-METHOXY-3-NITRO-BENZENEACETIC ACID METHYL ESTER(34837-88-2)Related Product Information

• 4-HYDROXY-3-NITROPHENYLACETIC ACID
• 4-METHOXY-3-NITRO-BENZENEACETIC ACID METHYL ESTER
• (4-METHOXY-3-NITROPHENYL)ACETIC ACID
• (3-NITROPHENYL)ACETIC ACID METHYL ESTER
• Methyl (4-Hydroxy-3-nitrophenyl)acetate
• methyl 2-(3-amino-4-hydroxyphenyl)acetate