INECALCITOL Chemical Properties

Boiling point:

568.6±50.0 °C(Predicted)

Density 

1.163

storage temp. 

4°C, protect from light, stored under nitrogen

solubility 

DMSO: Soluble

form 

Solid

pka

13.12±0.29(Predicted)

color 

Off-white to light yellow

INECALCITOL Usage And Synthesis

Uses

Inecalcitol is a derivative of Vitamin D (V676045), the vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity. It occurs in and is isolated from fish liver oils.

References

[1] GUY EELEN. Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction.[J]. Molecular Pharmacology, 2005, 67 5: 1566-1573. DOI: 10.1124/mol.104.008730
[2] L VERLINDEN. Two novel 14-Epi-analogues of 1,25-dihydroxyvitamin D3 inhibit the growth of human breast cancer cells in vitro and in vivo.[J]. Cancer research, 2000, 60 10: 2673-2679.
[3] PETRA DE HAES . 1,25-Dihydroxyvitamin D3 and analogues protect primary human keratinocytes against UVB-induced DNA damage[J]. Journal of photochemistry and photobiology. B, Biology, 2005, 78 2: Pages 141-148. DOI: 10.1016/j.jphotobiol.2004.09.010
[4] MICHAEL S K WONG. Vitamin D derivatives acutely reduce endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat.[J]. American journal of physiology. Heart and circulatory physiology, 2008, 295 1: H289-96. DOI: 10.1152/ajpheart.00116.2008

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