Basic information Safety Supplier Related

FALECALCITRIOL

Basic information Safety Supplier Related

FALECALCITRIOL Basic information

Product Name:
FALECALCITRIOL
Synonyms:
  • (+)-(5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1α,3β,25-triol
  • 26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D3
  • 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, 26,26,26,27,27,27-hexafluoro-, (1α,3β,5Z,7E)-
  • Flocalcitriol
  • Flocalcitrol
  • Fulstan
  • Hornel
  • Ro 23-4194
CAS:
83805-11-2
MF:
C27H38F6O3
MW:
524.58
Product Categories:
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
83805-11-2.mol
More
Less

FALECALCITRIOL Chemical Properties

Boiling point:
576.9±50.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C,unstable in solution, ready to use.
solubility 
Soluble in DMSO
form 
Powder
pka
9.77±0.29(Predicted)
More
Less

FALECALCITRIOL Usage And Synthesis

Description

Falecalcitriol, previously known as flocalcitrol, was launched by several codevelopers in Japan for the treatment of secondary hyperthyroidism (SHPT). This hexafluorinated analog of 1α,25-dihydroxyvitamin D3 (calcitriol), the hormonally active form of vitamin D3, can be obtained by several different synthetic routes from a conveniently protected cholestenol, a key step being an aldol reaction with hexafluoroacetone. Falecalcitriol is several times more active than 1,25(OH)2D3 in regulating the proliferation of parathyroid cells and parathyroid hormone (PTH) synthesis that are believed to be mediated through binding to VDR, a nuclear receptor for vitamin D; furthermore, it was proposed that a bioactive 23S-hydroxylated metabolite, resistant to further metabolism, contributes to the retention of an active compound for longer in cells and so, to significantly lengthen the duration of action. In a comparative clinical study conducted in hemodialysis patients with moderate to severe SHPT, falecalcitriol was found to be more active than alfacalcidol in suppressing parathyroid hormone without triggering hypercalcemia.

Originator

University of Wisconsin (US)

Uses

Hexafluorinated analog of Calcitriol (C144500). A more potent therapeutic agent for secondary hyperparathyroidism.

brand name

Hornel, Fulstan

Hazard

A poison by ingestion.

FALECALCITRIOLSupplier

Shandong Yizhi Medical Technology Co., LTD Gold
Tel
13287715206
Email
2786175817@qq.com
Wuhan Wsem Biological Co., Ltd. Gold
Tel
027-83778876 13667159345
Email
13667159345@163.com
Chemvon Biotechnology Co., Ltd
Tel
021-50790412
Email
info@chemvon.com
Chembest Research Laboratories Limited
Tel
021-20908456
Email
sales@BioChemBest.com
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Email
sales@chemreagents.com