FALECALCITRIOL

Product Name: FALECALCITRIOL
CAS No.: 83805-11-2
Chemical Name: FALECALCITRIOL
Synonyms: Hornel;ST 630;Fulstan;Ro 23-4194;Flocalcitrol;Flocacitriol;Falecalcitol;Flocalcitriol;F6-1,25(OH)2D3;FALECALCITRIOL
CBNumber: CB8849801
Molecular Formula: C27H38F6O3
Formula Weight: 524.58
MOL File: 83805-11-2.mol

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FALECALCITRIOL Property

Boiling point:: 576.9±50.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C,unstable in solution, ready to use.
solubility: Soluble in DMSO
form: Powder
pka: 9.77±0.29(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: F101110
Product name: Falecalcitriol
Packaging: 10mg
Price: $11000
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002674
Product name: FALECALCITRIOL
Purity: 95.00%
Packaging: 10MG
Price: $12127.5
Updated: 2021/12/16

ChemScene

Product number: CS-0801
Product name: Falecalcitriol
Purity: 95.09%
Packaging: 1mg
Price: $1056
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002674
Product name: FALECALCITRIOL
Purity: 95.00%
Packaging: 1MG
Price: $1424.85
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 17932
Product name: Falecalcitriol
Packaging: 1mg
Price: $1790
Updated: 2021/12/16

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FALECALCITRIOL Chemical Properties,Usage,Production

Description

Falecalcitriol, previously known as flocalcitrol, was launched by several codevelopers in Japan for the treatment of secondary hyperthyroidism (SHPT). This hexafluorinated analog of 1α,25-dihydroxyvitamin D3 (calcitriol), the hormonally active form of vitamin D3, can be obtained by several different synthetic routes from a conveniently protected cholestenol, a key step being an aldol reaction with hexafluoroacetone. Falecalcitriol is several times more active than 1,25(OH)₂D₃ in regulating the proliferation of parathyroid cells and parathyroid hormone (PTH) synthesis that are believed to be mediated through binding to VDR, a nuclear receptor for vitamin D; furthermore, it was proposed that a bioactive 23S-hydroxylated metabolite, resistant to further metabolism, contributes to the retention of an active compound for longer in cells and so, to significantly lengthen the duration of action. In a comparative clinical study conducted in hemodialysis patients with moderate to severe SHPT, falecalcitriol was found to be more active than alfacalcidol in suppressing parathyroid hormone without triggering hypercalcemia.

Originator

University of Wisconsin (US)

Uses

Hexafluorinated analog of Calcitriol (C144500). A more potent therapeutic agent for secondary hyperparathyroidism.

brand name

Hornel, Fulstan

Hazard

A poison by ingestion.

FALECALCITRIOL Preparation Products And Raw materials

Raw materials

Preparation Products

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FALECALCITRIOL Suppliers

Canada 1 China 72 India 1 United States 13 Global 87

Shandong Yizhi Medical Technology Co., LTD

Tel: 13287715206
Email: 2786175817@qq.com
Country: China
ProdList: 45
Advantage: 58

Wuhan Wsem Biological Co., Ltd.

Tel: 027-83778876 13667159345
Fax: 027-83778876
Email: 13667159345@163.com
Country: China
ProdList: 1940
Advantage: 55

Chemvon Biotechnology Co., Ltd

Tel: 021-50790412
Fax: +86-21-50790419
Email: info@chemvon.com
Country: China
ProdList: 371
Advantage: 57

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10194
Advantage: 62

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15421
Advantage: 60

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
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ChemStrong Scientific Co.,Ltd

Tel: 0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 17982
Advantage: 56

Zhengzhou TRIZ Pharmaceutical Technology Co., Ltd.

Tel: 19943855286
Fax: 0371-53392065
Email: Trizpharm@aliyun.com
Country: China
ProdList: 1869
Advantage: 56

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View Lastest Price from FALECALCITRIOL manufacturers

Career Henan Chemical Co

Product: FALECALCITRIOL 83805-11-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

83805-11-2, FALECALCITRIOLRelated Search:

5-(4-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-ethylidene}-7a-methyl-octahydro-inden-1-yl)-hexanoic acid ethyl ester methylene calcitriol INECALCITOL Calcitriol (S)-(-)-1,1,1-TRIFLUOROOCTAN-2-OL FALECALCITRIOL VitaMin D4 CALCIFEDIOL Calcifediol Monohydrate (S)-(-)-1,1,1-TRIFLUOROHEPTAN-2-OL 1,2-DIMETHYLENE-CYCLOHEXANE (S)-(-)-1,1,1-TRIFLUORODECAN-2-OL (R)-(+)-1 1 1-TRIFLUOROOCTAN-2-OL 97 (S)-(-)-1,1,1-TRIFLUORODODECAN-2-OL 1,1,1-TRIFLUORO-2-OCTANOL (S)-(-)-1,1,1-TRIFLUORONONAN-2-OL (S)-(-)-1,1,1-TRIFLUOROUNDECAN-2-OL (R)-(+)-1-FLUORO-2-OCTANOL

(+)-(5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1α,3β,25-triol

26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D3

9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, 26,26,26,27,27,27-hexafluoro-, (1α,3β,5Z,7E)-

Flocalcitriol

Flocalcitrol

Fulstan

Hornel

Ro 23-4194

ST 630

26,27-F6-1,25-(OH)2D3

F6-1,25(OH)2D3

26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol

26,27-Hexafluoro-1α,25-dihydroxyvitamine D3

FALECALCITRIOL

(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-Methyl-1-[(2R)-7,7,7-trifluoro-6-hydroxy-6-(trifluoromethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

(1R,4S,5Z)-4-Methylene-5-[(2E)-2-[1-[(1R)-6,6,6-trifluoro-5-hydroxy-1-Methyl-5-(trifluoroMethyl)hexyl]octahydro-7a-Methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol

(1α,3β,5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol

F6-1α,25-DihydroxyvitaMin D3

Flocacitriol

1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[1-[(1R)-6,6,6-trifluoro-5-hydroxy-1-methyl-5-(trifluoromethyl)hexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,4S,5Z)-

Falecalcitol

83805-11-2

C27H38F6O3

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Intermediates & Fine Chemicals

Pharmaceuticals