ChemicalBook > CAS DataBase List > FALECALCITRIOL

FALECALCITRIOL

Product Name: FALECALCITRIOL
CAS No.: 83805-11-2
Chemical Name: FALECALCITRIOL
Synonyms: Hornel;ST 630;Fulstan;Ro 23-4194;Fluorotriol;Flocalcitrol;Flocacitriol;Falecalcitol;Flocalcitriol;Falecalcitrio
CBNumber: CB8849801
Molecular Formula: C27H38F6O3
Formula Weight: 524.58
MOL File: 83805-11-2.mol

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FALECALCITRIOL Property

Boiling point:: 576.9±50.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C,unstable in solution, ready to use.
solubility: Soluble in DMSO
form: Powder
pka: 9.77±0.29(Predicted)
color: White to off-white
InChIKey: XPYGGHVSFMUHLH-QQAZGRHYNA-N
SMILES: [C@@H]1(O)C/C(=C\C=C2/CCCC3(C)C/2CC[C@@H]3C(C)CCCC(O)(C(F)(F)F)C(F)(F)F)/C(=C)C(O)C1 |&1:0,15,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: F101110
Product name: Falecalcitriol
Packaging: 10mg
Price: $11000
Updated: 2021/12/16

ChemScene

Product number: CS-0801
Product name: Falecalcitriol
Purity: 95.09%
Packaging: 1mg
Price: $1056
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002674
Product name: FALECALCITRIOL
Purity: 95.00%
Packaging: 1MG
Price: $1424.85
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 17932
Product name: Falecalcitriol
Packaging: 1mg
Price: $1790
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb612009
Product name: Falecalcitriol
Purity: >99%
Packaging: 100mg
Price: $2245.7
Updated: 2021/12/16

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FALECALCITRIOL Chemical Properties,Usage,Production

Description

Falecalcitriol, previously known as flocalcitrol, was launched by several codevelopers in Japan for the treatment of secondary hyperthyroidism (SHPT). This hexafluorinated analog of 1α,25-dihydroxyvitamin D3 (calcitriol), the hormonally active form of vitamin D3, can be obtained by several different synthetic routes from a conveniently protected cholestenol, a key step being an aldol reaction with hexafluoroacetone. Falecalcitriol is several times more active than 1,25(OH)₂D₃ in regulating the proliferation of parathyroid cells and parathyroid hormone (PTH) synthesis that are believed to be mediated through binding to VDR, a nuclear receptor for vitamin D; furthermore, it was proposed that a bioactive 23S-hydroxylated metabolite, resistant to further metabolism, contributes to the retention of an active compound for longer in cells and so, to significantly lengthen the duration of action. In a comparative clinical study conducted in hemodialysis patients with moderate to severe SHPT, falecalcitriol was found to be more active than alfacalcidol in suppressing parathyroid hormone without triggering hypercalcemia.

Originator

University of Wisconsin (US)

Uses

Hexafluorinated analog of Calcitriol (C144500). A more potent therapeutic agent for secondary hyperparathyroidism.

brand name

Hornel, Fulstan

Hazard

A poison by ingestion.

FALECALCITRIOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from FALECALCITRIOL manufacturers

Career Henan Chemical Co

Product: FALECALCITRIOL 83805-11-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

83805-11-2, FALECALCITRIOLRelated Search:

5-(4-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-ethylidene}-7a-methyl-octahydro-inden-1-yl)-hexanoic acid ethyl ester methylene calcitriol INECALCITOL Calcitriol (S)-(-)-1,1,1-TRIFLUOROOCTAN-2-OL FALECALCITRIOL VitaMin D4 CALCIFEDIOL Calcifediol Monohydrate (S)-(-)-1,1,1-TRIFLUOROHEPTAN-2-OL 1,2-DIMETHYLENE-CYCLOHEXANE (S)-(-)-1,1,1-TRIFLUORODECAN-2-OL (R)-(+)-1 1 1-TRIFLUOROOCTAN-2-OL 97 (S)-(-)-1,1,1-TRIFLUORODODECAN-2-OL 1,1,1-TRIFLUORO-2-OCTANOL (S)-(-)-1,1,1-TRIFLUORONONAN-2-OL (S)-(-)-1,1,1-TRIFLUOROUNDECAN-2-OL (R)-(+)-1-FLUORO-2-OCTANOL

(+)-(5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1α,3β,25-triol

26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D3

9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, 26,26,26,27,27,27-hexafluoro-, (1α,3β,5Z,7E)-

Flocalcitriol

Flocalcitrol

Fulstan

Hornel

Ro 23-4194

ST 630

26,27-F6-1,25-(OH)2D3

F6-1,25(OH)2D3

26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol

26,27-Hexafluoro-1α,25-dihydroxyvitamine D3

FALECALCITRIOL

(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-Methyl-1-[(2R)-7,7,7-trifluoro-6-hydroxy-6-(trifluoromethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

(1R,4S,5Z)-4-Methylene-5-[(2E)-2-[1-[(1R)-6,6,6-trifluoro-5-hydroxy-1-Methyl-5-(trifluoroMethyl)hexyl]octahydro-7a-Methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol

(1α,3β,5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol

F6-1α,25-DihydroxyvitaMin D3

Flocacitriol

1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[1-[(1R)-6,6,6-trifluoro-5-hydroxy-1-methyl-5-(trifluoromethyl)hexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,4S,5Z)-

Falecalcitol

(1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-7a-Methyl-1-((R)-7,7,7-trifluoro-6-hydroxy-6-(trifluoromethyl)heptan-2-yl)octahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol

Fluorocalcitriol

Fluorotriol

Falecalcitrio

83805-11-2

C27H38F6O3

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