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FALECALCITRIOL

Product Name
FALECALCITRIOL
CAS No.
83805-11-2
Chemical Name
FALECALCITRIOL
Synonyms
Hornel;ST 630;Fulstan;Ro 23-4194;Flocalcitrol;Flocacitriol;Falecalcitol;Flocalcitriol;F6-1,25(OH)2D3;FALECALCITRIOL
CBNumber
CB8849801
Molecular Formula
C27H38F6O3
Formula Weight
524.58
MOL File
83805-11-2.mol
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FALECALCITRIOL Property

Boiling point:
576.9±50.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C,unstable in solution, ready to use.
solubility 
Soluble in DMSO
form 
Powder
pka
9.77±0.29(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
F101110
Product name
Falecalcitriol
Packaging
10mg
Price
$11000
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002674
Product name
FALECALCITRIOL
Purity
95.00%
Packaging
10MG
Price
$12127.5
Updated
2021/12/16
ChemScene
Product number
CS-0801
Product name
Falecalcitriol
Purity
95.09%
Packaging
1mg
Price
$1056
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002674
Product name
FALECALCITRIOL
Purity
95.00%
Packaging
1MG
Price
$1424.85
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
17932
Product name
Falecalcitriol
Packaging
1mg
Price
$1790
Updated
2021/12/16
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FALECALCITRIOL Chemical Properties,Usage,Production

Description

Falecalcitriol, previously known as flocalcitrol, was launched by several codevelopers in Japan for the treatment of secondary hyperthyroidism (SHPT). This hexafluorinated analog of 1α,25-dihydroxyvitamin D3 (calcitriol), the hormonally active form of vitamin D3, can be obtained by several different synthetic routes from a conveniently protected cholestenol, a key step being an aldol reaction with hexafluoroacetone. Falecalcitriol is several times more active than 1,25(OH)2D3 in regulating the proliferation of parathyroid cells and parathyroid hormone (PTH) synthesis that are believed to be mediated through binding to VDR, a nuclear receptor for vitamin D; furthermore, it was proposed that a bioactive 23S-hydroxylated metabolite, resistant to further metabolism, contributes to the retention of an active compound for longer in cells and so, to significantly lengthen the duration of action. In a comparative clinical study conducted in hemodialysis patients with moderate to severe SHPT, falecalcitriol was found to be more active than alfacalcidol in suppressing parathyroid hormone without triggering hypercalcemia.

Originator

University of Wisconsin (US)

Uses

Hexafluorinated analog of Calcitriol (C144500). A more potent therapeutic agent for secondary hyperparathyroidism.

brand name

Hornel, Fulstan

Hazard

A poison by ingestion.

FALECALCITRIOL Preparation Products And Raw materials

Raw materials

Preparation Products

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FALECALCITRIOL Suppliers

Canada 1 China 76 India 1 United States 14 Global 92
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from FALECALCITRIOL manufacturers

Career Henan Chemical Co
Product
FALECALCITRIOL 83805-11-2
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-18

83805-11-2, FALECALCITRIOLRelated Search:

5-(4-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-ethylidene}-7a-methyl-octahydro-inden-1-yl)-hexanoic acid ethyl ester methylene calcitriol INECALCITOL Calcitriol (S)-(-)-1,1,1-TRIFLUOROOCTAN-2-OL FALECALCITRIOL VitaMin D4 CALCIFEDIOL Calcifediol Monohydrate (S)-(-)-1,1,1-TRIFLUOROHEPTAN-2-OL 1,2-DIMETHYLENE-CYCLOHEXANE (S)-(-)-1,1,1-TRIFLUORODECAN-2-OL (R)-(+)-1 1 1-TRIFLUOROOCTAN-2-OL 97 (S)-(-)-1,1,1-TRIFLUORODODECAN-2-OL 1,1,1-TRIFLUORO-2-OCTANOL (S)-(-)-1,1,1-TRIFLUORONONAN-2-OL (S)-(-)-1,1,1-TRIFLUOROUNDECAN-2-OL (R)-(+)-1-FLUORO-2-OCTANOL

  • (+)-(5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1α,3β,25-triol
  • 26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D3
  • 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, 26,26,26,27,27,27-hexafluoro-, (1α,3β,5Z,7E)-
  • Flocalcitriol
  • Flocalcitrol
  • Fulstan
  • Hornel
  • Ro 23-4194
  • ST 630
  • 26,27-F6-1,25-(OH)2D3
  • F6-1,25(OH)2D3
  • 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol
  • 26,27-Hexafluoro-1α,25-dihydroxyvitamine D3
  • FALECALCITRIOL
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-Methyl-1-[(2R)-7,7,7-trifluoro-6-hydroxy-6-(trifluoromethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
  • (1R,4S,5Z)-4-Methylene-5-[(2E)-2-[1-[(1R)-6,6,6-trifluoro-5-hydroxy-1-Methyl-5-(trifluoroMethyl)hexyl]octahydro-7a-Methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
  • (1α,3β,5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol
  • F6-1α,25-DihydroxyvitaMin D3
  • Flocacitriol
  • 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[1-[(1R)-6,6,6-trifluoro-5-hydroxy-1-methyl-5-(trifluoromethyl)hexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,4S,5Z)-
  • Falecalcitol
  • (1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-7a-Methyl-1-((R)-7,7,7-trifluoro-6-hydroxy-6-(trifluoromethyl)heptan-2-yl)octahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol
  • 83805-11-2
  • C27H38F6O3
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals