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VitaMin D4

Basic information Safety Supplier Related

VitaMin D4 Basic information

Product Name:
VitaMin D4
Synonyms:
  • RACUMIN D
  • OLEOVITAMIN D3
  • VITAMIN D
  • ANTI-RACHITIC VITAMIN
  • CALCIOL
  • CHOLECALCIFEROLUM
  • COLECALCIFEROL
  • 22-Dihydroergocalciferol
CAS:
511-28-4
MF:
C28H46O
MW:
398.66
EINECS:
208-127-5
Product Categories:
  • Steroids
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
511-28-4.mol
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VitaMin D4 Chemical Properties

Melting point:
83-86 °C(lit.)
alpha 
D18 +89.3° (c = 0.47 in acetone)
Boiling point:
504.9±29.0 °C(Predicted)
Density 
0.96
storage temp. 
2-8°C
pka
14.74±0.20(Predicted)
CAS DataBase Reference
511-28-4(CAS DataBase Reference)
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Safety Information

Hazard Codes 
T+
Risk Statements 
24/25-26-48/25
Safety Statements 
28-36/37
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
2
RTECS 
VS2900000
8-10-23

MSDS

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VitaMin D4 Usage And Synthesis

Description

Derived from cholesterol, vitamin D is biosynthesized from its prohormone cholecalciferol (D3), the product of solar ultraviolet irradiation of 7-dehydrocholesterol in the skin. In 1966, it was first recognized that vitamin D must undergo activation via two oxidative metabolic steps. The first oxidation to 25-hydroxycholecalciferol (25(OH)D3: calcifediol; Calderol) occurs in the endoplasmic reticulum of the liver and is catalyzed by vitamin D 25-hydroxylase. This activation step is not regulated by plasma calcium concentrations. The major circulating form (10–80 μg/mL) is 25(OH)D3, which also is the primary storage form of vitamin D.

Chemical Properties

Pale Yellow Oil

Uses

Vitamin D4 is the active analogue of Vitamin D.

Biological Functions

Sterol-specific cytoplasmic receptor proteins (vitamin D receptor) mediate the biological action of vitamin D. The active hormone is transported from the cytoplasm to the nucleus via the vitamin D receptor, and as a result of the interaction of the hormone with target genes, a variety of proteins are produced that stimulate the transport of calcium in each of the target tissues Active vitamin D works in concert with PTH to enhance active intestinal absorption of calcium, to stimulate bone resorption, and to prohibit renal excretion of calcium. If serum calcium or 1,25-calcitriol concentrations are elevated, then vitamin D 24-hydroxylase (in renal mitochondria) is activated to oxidize 25(OH)D3 to inactive 24,25-dihydroxy-cholecalciferol and to further oxidize active vitamin D to the inactive 1,24,25-trihydroxylated derivative. Both the 1,24,25-trihydroxylated and the 24,25-dihydroxylated products have been found to suppress PT H secretion as well. The biosynthesis of vitamin D is tightly regulated based on the serum concentrations of calcium, phosphate, PTH, and active vitamin D.

VitaMin D4Supplier

Chemvon Biotechnology Co., Ltd
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021-50790412-
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info@chemvon.com
3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801
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3bsc@sina.com
Chembest Research Laboratories Limited
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021-20908456-
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sales@BioChemBest.com
Chemsky(shanghai)International Co.,Ltd.
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021-50135380
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shchemsky@sina.com
BOC Sciences
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info@bocsci.com