Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Vitamins and Minerals medicines >  Vitamins AD drugs >  Retinyl acetate

Retinyl acetate

Basic information Safety Supplier Related

Retinyl acetate Basic information

Product Name:
Retinyl acetate
Synonyms:
  • RETINYL ACETATE
  • RETINOL ACETATE
  • RETINOL ACETATE ALL TRANS
  • RETINOL ACETATE, WATER SOLUBLE
  • VITAMIN A ACETATE, ALL TRANS
  • VITAMIN A ACETATE 1500
  • VITAMIN A ACETATE
  • TRANS-RETINOL ACETATE
CAS:
127-47-9
MF:
C22H32O2
MW:
328.49
EINECS:
204-844-2
Product Categories:
  • Vitamin series
  • Retinoids
  • Vitamins and derivatives
  • Vitamin Ingredients
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Inhibitors
  • 127-47-9
Mol File:
127-47-9.mol
More
Less

Retinyl acetate Chemical Properties

Melting point:
57-58 °C
Boiling point:
406.22°C (rough estimate)
Density 
1.0474 (rough estimate)
refractive index 
1.547-1.555
Flash point:
14℃
storage temp. 
2-8°C
solubility 
absolute ethanol: 25 mg/mL
form 
solid or viscous liquid
color 
Yellow powder
Odor
Amine like
Water Solubility 
soluble
Sensitive 
Light & Air Sensitive & Hygroscopic
Merck 
14,10013
BRN 
1915439
Stability:
Hygroscopic, Light Sensitive
InChIKey
QGNJRVVDBSJHIZ-QHLGVNSISA-N
LogP
9.4 at 25℃
CAS DataBase Reference
127-47-9(CAS DataBase Reference)
NIST Chemistry Reference
Retinol, acetate(127-47-9)
EPA Substance Registry System
Retinol acetate (127-47-9)
More
Less

Safety Information

Hazard Codes 
Xn,Xi,T,F
Risk Statements 
38-63-36/37/38-53-61-11
Safety Statements 
36/37-45-37/39-26-53-16
RIDADR 
UN1170 - class 3 - PG 2 - Ethanol
WGK Germany 
2
RTECS 
VH6825000
1-8-10
TSCA 
Yes
HS Code 
29362100
Toxicity
LD50 (10 day) orally in mice: 4100 mg/kg (Kamm)

MSDS

More
Less

Retinyl acetate Usage And Synthesis

Description

Retinyl acetate (retinol acetate, vitamin A acetate,127-47-9) is a natural form of vitamin A. It is the acetate ester of retinol. It consists of yellow crystals which are greasy or sticky. It has a mild, characteristic odor. It has potential antineoplastic and chemo-preventive activities. It can be used to fortify food with vitamin A. As vitamin A acetate can induce cell differentiation and inhibit cell proliferation, it is used in skin-conditioning agent.

Chemical Properties

Retinyl acetate is a yellow, prism-shaped crystal and a lipid-soluble compound, with better chemical stability than vitamin A. In clinical practice, either vitamin A acetate or its palmitate form is typically dissolved in vegetable oil for administration, where it is hydrolyzed by enzymes in the body to release active vitamin A. The form of vitamin A listed in the Chinese Pharmacopoeia refers to the active vitamin A compound.

Uses

Essential micronutrient

Uses

vitamin precursor

Uses

Retinyl acetate has been used:

  • a control diet to study its effect at different developmental periods in fish larvae
  • to study its inhibitory effects on Mycobacterium avium?subspecies?paratuberculosis?(MAP) strains
  • as an internal standard in high performance liquid chromatography (HPLC) to quantify vitamin A in fortified milk

Preparation

A method for preparing retinyl acetate the following steps:
Under alkaline conditions, 3-methyl-4-oxo-2-butene-1-yl acetate (referred to as C5 aldehyde ester) and tetraethyl methylene diphosphate undergo a condensation reaction to form an intermediate C6 phosphate (chemical name: 5-(diethyl phosphate)-3-methyl-2,4-hexadiene-1-acetate).
Under alkaline conditions, the C6 phosphate undergoes a transposition reaction. C14 aldehyde (chemical name: 2-methyl-4-(2,6,6-trimethyl-1-cyclohexene-1-yl)-3-butene-1-aldehyde) is then added to undergo a Wittig-Horner condensation reaction, yielding retinyl acetate.

Definition

ChEBI: Retinyl acetate is an acetate ester. It is functionally related to an all-trans-retinol.

General Description

Retinyl acetate is suitable for use in the retention identification of the analyte when using HPLC and GC. Not intended for use as an activity reference standard. It has been thoroughly evaluated to ensure the utmost quality. Neat, unless otherwise noted. Certificate of Composition provided with the purchase.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as required. Retinyl acetate is used in a wide range of biological applications. It acts as a chemopreventive agent. Retinyl acetate also has antineoplastic property.

Safety Profile

Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also VITAMIN A.

Purification Methods

The acetate is separated from retinol by column chromatography, then crystallised from MeOH. [Kofler and Rubin Vitamins and Hormones (NY) 18 315 1960 for purification methods]. Store it in the dark, under N2 or Ar, at 0o. [Beilstein 6 IV 4135.]

References

[1] Volker Bühler, Vademecum for Vitamin Formulations, 2001, ISBN 3-8047-1834-5
[2] SUNATDA ARAYACHUKEAT Thapakorn T U Supason P Wanichwecharungruang. Retinyl acetate-loaded nanoparticles: Dermal penetration and release of the retinyl acetate[J]. International Journal of Pharmaceutics, 2011, 404 1: Pages 281-288. DOI:10.1016/j.ijpharm.2010.11.019.
[3] HARRISON E H. Lipases and carboxylesterases: possible roles in the hepatic metabolism of retinol.[J]. Annual review of nutrition, 1998, 18: 259-276. DOI:10.1146/annurev.nutr.18.1.259.
[4] GERSTER H. Vitamin A–functions, dietary requirements and safety in humans.[J]. International Journal for Vitamin and Nutrition Research, 1997, 67 2: 71-90.
[5] https://ods.od.nih.gov/factsheets/VitaminA-HealthProfessional/

Retinyl acetateSupplier

future industrial shanghai co., ltd Gold
Tel
400-0066400 13621662912
Email
sales@jonln.com
Hebei Zhentian Food Additives Co., Ltd. Gold
Tel
0319-5925599 13373390591
Email
13933732699@163.com
Spec-Chem Industry Inc. Gold
Tel
025-84523390 13505162978
Email
sc@specchemind.com
Hubei wei shi reagent group ltd., company Gold
Tel
027-59102966 18717199209
Email
2853877583@QQ.com
Hebei Zhentian food additives Co., LTD Gold
Tel
0319-5925599 13373390591
Email
13933732699@163.com