CILANSETRON Chemical Properties

Boiling point:

600.6±50.0 °C(Predicted)

Density 

1.36±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

7.50±0.33(Predicted)

CILANSETRON Usage And Synthesis

Uses

5-HT3 antagonist 3 (Compound 15b) is a high-affinity 5-HT3 receptor antagonist. 5-HT3 antagonist 3 binds to 5-HT3 receptors in rat brain cortical membranes with Ki of 0.25 nM[1].

IC 50

5-HT₃ Receptor: 0.25 nM (Ki)

References

[1] van Wijngaarden I, et al. Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives. J Med Chem. 1993 Nov 12;36(23):3693-9. DOI:10.1021/jm00075a026

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