Tolbutamide-d9 Chemical Properties

Melting point:

108-111°C

storage temp. 

Refrigerator

solubility 

DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.14 mg/ml

form 

A solid

color 

White to off-white

Tolbutamide-d9 Usage And Synthesis

Description

Tolbutamide-d₉ is intended for use as an internal standard for the quantification of tolbutamide by GC- or LC-MS. Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel K_ir6.2 (IC₅₀ = 4.9 μM). It is selective for SUR1/K_ir6.2 over SUR2A/K_ir6.2 and SUR2B/K_ir6.2 channels (IC₅₀s = 85 and 88 μM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets. In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ; ). Formulations containing tolbutamide have been used in the treatment of type 2 diabetes.

Chemical Properties

White Solid

Uses

Labelled Tolbutamide (T535150). An antidiabetic, used as a hypoglycemic agent in veterinary medicine.

Tolbutamide-d9(1219794-57-6)Related Product Information

• TOLAZAMIDE
• Tolbutamide Impurity 5
• 4-Carboxytolbutamide Methyl Ester
• TOLBUTAMIDE
• Tolbutamide 4-Carboxy Ethyl Ester
• 4-Hydroxytolbutamide