3-HYDROXYPHTHALIC ANHYDRIDE Chemical Properties

Melting point:

199-202 °C (lit.)

Boiling point:

365.4±25.0 °C(Predicted)

Density 

1.624±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Acetonitrile (Slightly), DMSO (Slightly)

pka

6.25±0.20(Predicted)

form 

Powder

color 

White to beige

BRN 

135783

Stability:

Hygroscopic

InChIKey

CCTOEAMRIIXGDJ-UHFFFAOYSA-N

CAS DataBase Reference

37418-88-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

TI3300000

F 

21

HS Code 

29182900

Toxicity

mouse,LD50,intravenous,75mg/kg (75mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#08845,

MSDS

• Language:English Provider:SigmaAldrich

3-HYDROXYPHTHALIC ANHYDRIDE Usage And Synthesis

Uses

3-Hydroxyphthalic Anhydride is used to synthesize 3-Hydroxyphthalic Anhydride-modified human serum albumin whichhas high potency as a microbicide for prevention of the sexual transmission of HIV. It is also used as a reagent in organicsynthesis of other compounds including that of inhibitors of NF-κB derived from thalidomide.

Chemical Properties

Beige powder

Uses

3-Hydroxyphthalic Anhydride is used to synthesize 3-Hydroxyphthalic Anhydride-modified human serum albumin whichhas high potency as a microbicide for prevention of the sexual transmission of HIV. It is also used as a reagent in organicsynthesis of other compounds including that of inhibitors of NF-κB derived from thalidomide.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 5092, 1955 DOI: 10.1021/ja01624a042
Synthesis, p. 788, 1985 DOI: 10.1055/s-1985-31350

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